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Pathway Description
4-Aminobutanoate Degradation
Saccharomyces cerevisiae
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2015-12-10
Last Updated: 2025-01-25
GABA(γ-aminobutyric acid) is a non-protein amino acid that can be accumulated via permease-mediated uptake by Uga4p, Put4p, and Gap1p. GABA can also be produced via glutamate degradation by the glutamate decarboxylase, this variant of the pathway includes a 2-oxoglutarate-dependent 4-aminobutyrate transaminase and an NAD+-dependent dehydrogenase. This combination of enzymes has been documented in bacteria and animals and in some plants. Regarding the hydrogenase, NAD-specific variants have been studied from many bacteria, plant and animals.
References
4-Aminobutanoate Degradation References
Coleman ST, Fang TK, Rovinsky SA, Turano FJ, Moye-Rowley WS: Expression of a glutamate decarboxylase homologue is required for normal oxidative stress tolerance in Saccharomyces cerevisiae. J Biol Chem. 2001 Jan 5;276(1):244-50. doi: 10.1074/jbc.M007103200.
Pubmed: 11031268
Idicula AM, Blatch GL, Cooper TG, Dorrington RA: Binding and activation by the zinc cluster transcription factors of Saccharomyces cerevisiae. Redefining the UASGABA and its interaction with Uga3p. J Biol Chem. 2002 Nov 29;277(48):45977-83. doi: 10.1074/jbc.M201789200. Epub 2002 Sep 13.
Pubmed: 12235130
Ramos F, el Guezzar M, Grenson M, Wiame JM: Mutations affecting the enzymes involved in the utilization of 4-aminobutyric acid as nitrogen source by the yeast Saccharomyces cerevisiae. Eur J Biochem. 1985 Jun 3;149(2):401-4.
Pubmed: 3888627
Vissers S, Andre B, Muyldermans F, Grenson M: Positive and negative regulatory elements control the expression of the UGA4 gene coding for the inducible 4-aminobutyric-acid-specific permease in Saccharomyces cerevisiae. Eur J Biochem. 1989 May 1;181(2):357-61.
Pubmed: 2653828
Krzywicki KA, Brandriss MC: Primary structure of the nuclear PUT2 gene involved in the mitochondrial pathway for proline utilization in Saccharomyces cerevisiae. Mol Cell Biol. 1984 Dec;4(12):2837-42. doi: 10.1128/mcb.4.12.2837.
Pubmed: 6098824
Johnston M, Andrews S, Brinkman R, Cooper J, Ding H, Dover J, Du Z, Favello A, Fulton L, Gattung S, et al.: Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII. Science. 1994 Sep 30;265(5181):2077-82. doi: 10.1126/science.8091229.
Pubmed: 8091229
Engel SR, Dietrich FS, Fisk DG, Binkley G, Balakrishnan R, Costanzo MC, Dwight SS, Hitz BC, Karra K, Nash RS, Weng S, Wong ED, Lloyd P, Skrzypek MS, Miyasato SR, Simison M, Cherry JM: The reference genome sequence of Saccharomyces cerevisiae: then and now. G3 (Bethesda). 2014 Mar 20;4(3):389-98. doi: 10.1534/g3.113.008995.
Pubmed: 24374639
Casas C, Aldea M, Casamayor A, Lafuente MJ, Gamo FJ, Gancedo C, Arino J, Herrero E: Sequence analysis of a 9873 bp fragment of the left arm of yeast chromosome XV that contains the ARG8 and CDC33 genes, a putative riboflavin synthase beta chain gene, and four new open reading frames. Yeast. 1995 Sep 15;11(11):1061-7. doi: 10.1002/yea.320111107.
Pubmed: 7502581
Heimberg H, Boyen A, Crabeel M, Glansdorff N: Escherichia coli and Saccharomyces cerevisiae acetylornithine aminotransferase: evolutionary relationship with ornithine aminotransferase. Gene. 1990 May 31;90(1):69-78. doi: 10.1016/0378-1119(90)90440-3.
Pubmed: 2199330
Dujon B, Albermann K, Aldea M, Alexandraki D, Ansorge W, Arino J, Benes V, Bohn C, Bolotin-Fukuhara M, Bordonne R, Boyer J, Camasses A, Casamayor A, Casas C, Cheret G, Cziepluch C, Daignan-Fornier B, Dang DV, de Haan M, Delius H, Durand P, Fairhead C, Feldmann H, Gaillon L, Kleine K, et al.: The nucleotide sequence of Saccharomyces cerevisiae chromosome XV. Nature. 1997 May 29;387(6632 Suppl):98-102.
Pubmed: 9169874
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