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S-
adenosylmethionine
synthetase
S-
AdenosylMethionine
requiring
S-adenosyl-L-
homocysteine
hydrolase
aromatic amino
acid
aminotransferase
II
acireductone
dioxygenase
2,3-
dioxomethiopentane-
1-phosphate
enolase/phosphatase
Methylthioribulose-
1-phosphate
DEhydratase
MethylthioRibose-
1-phosphate
Isomerase
5'-
methylthioadenosine
phosphorylase
Aspartokinase
aspartic beta
semi-aldehyde
dehydrogenase
Homoserine
dehydrogenase
homoserine
O-trans-acetylase
Putative
cystathionine
beta-lyase
N5-
methyltetrahydropteroyltriglutamate-
homocysteine
methyltransferase
L-Methionine
ATP
H
2
O
P
i
PP
i
S-
Adenosylmethionine
H
+
S-
Adenosylhomocysteine
H
2
O
Adenosine
Homocysteine
2-Oxo-4-
methylthiobutanoic
acid
L-Phenylalanine
2-Ketobutyric
acid
1,2-Dihydroxy-
3-keto-5-
methylthiopentene
O
2
H
+
Formic acid
H
2
O
5-(Methylthio)-
2,3-dioxopentyl
phosphate
H
+
P
i
5-
Methylthioribulose
1-phosphate
H
2
O
5-
Methylthioribose
1-phosphate
P
i
5'-S-methyl-5'-
thioadenosine
Adenine
L-Aspartic acid
ATP
ADP
L-Aspartyl-4-
phosphate
NADPH
H
+
P
i
NADP
L-Aspartate-
semialdehyde
NADPH
H
+
L-Homoserine
NADP
Acetyl-CoA
CoA
Acetylhomoserine
Hydrogen sulfide
Acetic acid
H
+
5-
Methyltetrahydropteroyltri-
L-glutamate
Tetrahydropteroyltri-
L-glutamate
a demethylated
methyl donor
a methylated
methyl donor
Endocytosis
SAM1
SAM2
SAH1
ARO9
ADI1
UTR4
MDE1
MRI1
MEU1
HOM3