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Pathway Description
Mannose Metabolism
Saccharomyces cerevisiae
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2015-12-22
Last Updated: 2019-08-14
Mannose is metabolized through the phosphorylation of mannose by a mannokinase resulting in a D-mannopyranose 6-phosphate. The latter compound is isomerized into a B-D-fructofuranose 6-phosphate which can either be incorporated into glycolysis or it can be further be metabolized into a mannose 1-phosphate through a phosphomannomutase. Mannose 1-phosphate then react with a gdp and a hydrogen ion to produce GDP-alpha-D-mannose
References
Mannose Metabolism References
Albright CF, Orlean P, Robbins PW: A 13-amino acid peptide in three yeast glycosyltransferases may be involved in dolichol recognition. Proc Natl Acad Sci U S A. 1989 Oct;86(19):7366-9.
Pubmed: 2678101
Babczinski P, Haselbeck A, Tanner W: Yeast mannosyl transferases requiring dolichyl phosphate and dolichyl phosphate mannose as substrate. Partial purification and characterization of the solubilized enzyme. Eur J Biochem. 1980 Apr;105(3):509-15.
Pubmed: 6989607
Lobo Z, Maitra PK: Genetics of yeast hexokinase. Genetics. 1977 Aug;86(4):727-44.
Pubmed: 17248750
Kopetzki E, Entian KD, Mecke D: Complete nucleotide sequence of the hexokinase PI gene (HXK1) of Saccharomyces cerevisiae. Gene. 1985;39(1):95-101. doi: 10.1016/0378-1119(85)90113-1.
Pubmed: 3908224
Stachelek C, Stachelek J, Swan J, Botstein D, Konigsberg W: Identification, cloning and sequence determination of the genes specifying hexokinase A and B from yeast. Nucleic Acids Res. 1986 Jan 24;14(2):945-63. doi: 10.1093/nar/14.2.945.
Pubmed: 3003701
Murakami Y, Naitou M, Hagiwara H, Shibata T, Ozawa M, Sasanuma S, Sasanuma M, Tsuchiya Y, Soeda E, Yokoyama K, et al.: Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae. Nat Genet. 1995 Jul;10(3):261-8. doi: 10.1038/ng0795-261.
Pubmed: 7670463
Frohlich KU, Entian KD, Mecke D: The primary structure of the yeast hexokinase PII gene (HXK2) which is responsible for glucose repression. Gene. 1985;36(1-2):105-11. doi: 10.1016/0378-1119(85)90074-5.
Pubmed: 3905511
Coissac E, Maillier E, Robineau S, Netter P: Sequence of a 39,411 bp DNA fragment covering the left end of chromosome VII of Saccharomyces cerevisiae. Yeast. 1996 Dec;12(15):1555-62. doi: 10.1002/(SICI)1097-0061(199612)12:15%3C1555::AID-YEA43%3E3.0.CO;2-Q.
Pubmed: 8972578
Smith DJ, Proudfoot A, Friedli L, Klig LS, Paravicini G, Payton MA: PMI40, an intron-containing gene required for early steps in yeast mannosylation. Mol Cell Biol. 1992 Jul;12(7):2924-30. doi: 10.1128/mcb.12.7.2924.
Pubmed: 1377774
Dietrich FS, Mulligan J, Hennessy K, Yelton MA, Allen E, Araujo R, Aviles E, Berno A, Brennan T, Carpenter J, Chen E, Cherry JM, Chung E, Duncan M, Guzman E, Hartzell G, Hunicke-Smith S, Hyman RW, Kayser A, Komp C, Lashkari D, Lew H, Lin D, Mosedale D, Davis RW, et al.: The nucleotide sequence of Saccharomyces cerevisiae chromosome V. Nature. 1997 May 29;387(6632 Suppl):78-81.
Pubmed: 9169868
Engel SR, Dietrich FS, Fisk DG, Binkley G, Balakrishnan R, Costanzo MC, Dwight SS, Hitz BC, Karra K, Nash RS, Weng S, Wong ED, Lloyd P, Skrzypek MS, Miyasato SR, Simison M, Cherry JM: The reference genome sequence of Saccharomyces cerevisiae: then and now. G3 (Bethesda). 2014 Mar 20;4(3):389-98. doi: 10.1534/g3.113.008995.
Pubmed: 24374639
Bernstein M, Hoffmann W, Ammerer G, Schekman R: Characterization of a gene product (Sec53p) required for protein assembly in the yeast endoplasmic reticulum. J Cell Biol. 1985 Dec;101(6):2374-82. doi: 10.1083/jcb.101.6.2374.
Pubmed: 3905826
Leh-Louis V, Wirth B, Despons L, Wain-Hobson S, Potier S, Souciet JL: Differential evolution of the Saccharomyces cerevisiae DUP240 paralogs and implication of recombination in phylogeny. Nucleic Acids Res. 2004 Apr 15;32(7):2069-78. doi: 10.1093/nar/gkh529. Print 2004.
Pubmed: 15087486
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