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Pathway Description
Glycerol Metabolism
Saccharomyces cerevisiae
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2016-01-12
Last Updated: 2019-09-12
The glycerol metabolism begins with the reversible reaction of 3-phosphoglyceric acid to glyceric acid through a D-glycerate 3-kinase. Glyceric acid then reacts with a NADH driven aldehyde dehydrogenase resulting in the release of water and glyceraldehyde. Glyceraldehyde is then turned to glycerol through an alcohol dehydrogenase.
Glycerol can then either react in a reversible reaction with a glycerol dehydrogenase resulting in the release of dihydroxyacetone. On the other hand glycerol can be phosphorylated through a glycerol kinase resulting in the release of glycerol 3 phosphate. Both glycerol 3 phosphate and dihydroxyacetone lead to the production of 1-oleyl-2-lyso-phosphatidate. Dihydroxyacetone is then phosphorylated through a dihydroxyacetone kinase resulting in the release of glycerone phosphate. Glycerone phosphate reacts with oleoyl-CoA (an acyl-CoA) through a glycerol-3-phosphate O-acyltransferase resulting in the release of 1-oleoyl-2-lyso-glycerone phosphate.
Glycerol 3 phosphate can go back to a glycerol through a glycerol 3-phosphatase. It can also be react with a oleoyl-CoA through a glycerol-3-phosphate O-acyltransferase resulting in the release of 1-oleyl-2-lyso-phosphatidate. This compound reacts with an oleoyl-CoA through a Lysophosphatidic acid:oleoyl-CoA acyltransferase resulting in the release of a dioleoyl phosphatidate
References
Glycerol Metabolism References
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Pubmed: 8358828
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Pubmed: 8091229
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Pubmed: 7500933
Churcher C, Bowman S, Badcock K, Bankier A, Brown D, Chillingworth T, Connor R, Devlin K, Gentles S, Hamlin N, Harris D, Horsnell T, Hunt S, Jagels K, Jones M, Lye G, Moule S, Odell C, Pearson D, Rajandream M, Rice P, Rowley N, Skelton J, Smith V, Barrell B, et al.: The nucleotide sequence of Saccharomyces cerevisiae chromosome IX. Nature. 1997 May 29;387(6632 Suppl):84-7.
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Norbeck J, Pahlman AK, Akhtar N, Blomberg A, Adler L: Purification and characterization of two isoenzymes of DL-glycerol-3-phosphatase from Saccharomyces cerevisiae. Identification of the corresponding GPP1 and GPP2 genes and evidence for osmotic regulation of Gpp2p expression by the osmosensing mitogen-activated protein kinase signal transduction pathway. J Biol Chem. 1996 Jun 7;271(23):13875-81. doi: 10.1074/jbc.271.23.13875.
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Pubmed: 9169868
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