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Mitochondria
Homocitrate
synthase,
mitochondrial
Homocitrate
synthase,
cytosolic
isozyme
Homoaconitase,
mitochondrial
Homoisocitrate
dehydrogenase,
mitochondrial
L-2-
aminoadipate
reductase
L-2-
aminoadipate
reductase
Saccharopine
dehydrogenase
[NADP(+),
L-glutamate-
forming]
Saccharopine
dehydrogenase
[NAD(+),
L-lysine-
forming]
Oxoglutaric
acid
Acetyl-CoA
H
2
O
CoA
Homocitric acid
H
+
Oxoglutaric
acid
Acetyl-CoA
H
2
O
Homocitric acid
CoA
H
+
H
2
O
cis-
homoaconitate
H
2
O
(1R,2S)-
homoisocitrate
NAD
CO
2
NADH
Oxoadipic acid
L-Glutamic acid
Oxoglutaric
acid
Aminoadipic
acid
ATP
PP
i
AMP
H
+
NADPH
NADP
Allysine
NADPH
L-Glutamic acid
H
+
H
2
O
NADP
Saccharopine
NAD
H
2
O
NADH
H
+
Oxoglutaric
acid
L-Lysine
H
2
O
holo-[LYS2
peptidyl-
carrier-
protein]
L-2-
aminoadipyl-
[LYS2 peptidyl-
carrier-
protein]
holo-[LYS2
peptidyl-
carrier-
protein]
Mitochondria
LYS21
LYS20
LYS4
LYS12
LYS2
LYS2
LYS9
LYS1
Oxoglutaric
acid
Acetyl-CoA
Water
Coenzyme A
Homocitric acid
Hydrogen Ion
Oxoglutaric
acid
Acetyl-CoA
Water
Homocitric acid
Coenzyme A
Hydrogen Ion
Water
cis-
homoaconitate
Water
(1R,2S)-
homoisocitrate
NAD
Carbon dioxide
NADH
Oxoadipic acid
L-Glutamic acid
Oxoglutaric
acid
Aminoadipic
acid
Adenosine
triphosphate
Pyrophosphate
Adenosine
monophosphate
Hydrogen Ion
NADPH
NADP
Allysine
NADPH
L-Glutamic acid
Hydrogen Ion
Water
NADP
Saccharopine
NAD
Water
NADH
Hydrogen Ion
Oxoglutaric
acid
L-Lysine
Water
holo-[LYS2
peptidyl-
carrier-
protein]
L-2-
aminoadipyl-
[LYS2 peptidyl-
carrier-
protein]
holo-[LYS2
peptidyl-
carrier-
protein]