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branched-chain
amino-acid
aminotransferase
2-
isopropylmalate
synthase
isopropylmalate
isomerase
isopropylmalate
isomerase
isopropylmalate
isomerase
isopropylmalate
isomerase
D-malate / 3-
isopropylmalate
dehydrogenase
(decarboxylating)
tyrosine
aminotransferase
3-Methyl-2-
oxovaleric acid
H
2
O
Acetyl-CoA
CoA
H
+
2-
Isopropylmalic
acid
H
2
O
Isopropylmaleate
H
2
O
3-
Isopropylmalate
NAD
NADH
H
+
2-Isopropyl- 3-
oxosuccinate
H
+
CO
2
Ketoleucine
L-Glutamic acid
Oxoglutaric
acid
L-Leucine
Isoleucine
Biosynthesis
3-
isopropylmalate
dehydrogenase
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
3-Methyl-2-
oxovaleric acid
Water
Acetyl-CoA
Coenzyme A
Hydrogen Ion
2-
Isopropylmalic
acid
Water
Isopropylmaleate
Water
3-
Isopropylmalate
NAD
NADH
Hydrogen Ion
2-Isopropyl- 3-
oxosuccinate
Hydrogen Ion
Carbon dioxide
Ketoleucine
L-Glutamic acid
Oxoglutaric
acid
L-Leucine
Isoleucine
Biosynthesis
Unknown
3M2Oxva
H
2
O
Ac-CoA
CoA
H
+
2-Isopa
H
2
O
Isoprop
H
2
O
3Isopr
NAD
NADH
H
+
2ip3o
H
+
CO
2
Ketoleu
Glu
AKG
Leu
PW002476