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Endoplasmic Reticulum 3-ketoacyl-CoA thiolase, peroxisomal Hydroxymethylglutaryl- CoA synthase mevalonate kinase Phosphomevalonate kinase Diphosphomevalonate decarboxylase Isopentenyl- diphosphate Delta-isomerase Squalene monooxygenase Lanosterol synthase Delta(24)- sterol reductase Lanosterol 14-alpha demethylase Delta(14)- sterol reductase 3-hydroxy-3- methylglutaryl- coenzyme A reductase 1 3-hydroxy-3- methylglutaryl- coenzyme A reductase 2 C-4 sterol methyl oxidase Methylsterol monooxygenase Methylsterol monooxygenase C-3 sterol dehydrogenase 3-keto sterol reductase Methylsterol monooxygenase Methylsterol monooxygenase Methylsterol monooxygenase C-3 sterol dehydrogenase 3-keto sterol reductase Sterol 24-C- methyltransferase C-8 sterol isomerase C-5 sterol desaturase C-22 sterol desaturase C-24 sterol reductase Geranylgeranyl pyrophosphate synthase BTS1 Geranylgeranyl pyrophosphate synthase BTS1 Squalene synthase Farnesyl pyrophosphate synthase Farnesyl pyrophosphate synthase Acetoacetyl-CoA Acetyl-CoA CoA H2O 3-Hydroxy-3-methylglutaryl-CoA CoA Mevalonic acid ATP Mevalonic acid-5P ADP ATP ADP (R)-5-Diphosphomevalonic acid ATP ADP Pi Isopentenyl pyrophosphate CO2 Dimethylallylpyrophosphate Squalene O2 NADPH (S)-2,3-Epoxysqualene H2O NADP Lanosterol NADPH 24,25-Dihydrolanosterol NADP O2 NADPH 4,4-Dimethylcholesta- 8,14,24-trienol Formic acid NADP H2O NADPH 4,4-Dimethyl-5a-cholesta- 8,24-dien-3-b-ol NADP NADPH NADP CoA H+ O2 NADPH 4α-hydroxymethyl-4β-methyl- 5α-cholesta-8,24-dien-3β-ol NADP H2O H+ O2 NADPH 4α-formyl-4β-methyl-5α- cholesta-8,24-dien-3β-ol H2O NADP O2 NADPH 4β-methyl-4α-carboxy- cholesta-8,24-dien-3β-ol H2O NADP NADP 3-Keto-4-methylzymosterol CO2 NADPH NADPH H+ NADP 4a-Methylzymosterol H+ O2 NADPH H2O NADP 4α-hydroxymethyl-5α- cholesta-8,24-dien-3β-ol H+ O2 NADPH 4α-formyl-5α-cholesta-8,24- dien-3β-ol H2O NADP O2 NADPH 4α-carboxy-5α-cholesta-8,24- dien-3β-ol H2O NADP NADP 5α-cholesta-8,24-dien-3-one CO2 NADPH NADPH H+ Zymosterol NADP S-Adenosylmethionine fecosterol S-Adenosylhomocysteine H+ Episterol H+ O2 ferrocytochrome c 5,7,24(28)-Ergostatrienol H2O ferricytochrome c H+ NADPH O2 ergosta-5,7,22,24(28)- tetraen-3-β-ol NADP H2O H+ NADPH Ergosterol NADP Geranyl-PP PPi Farnesyl pyrophosphate PPi NADPH NADP PPi Magnesium Magnesium Magnesium Magnesium Butyrate Metabolism Pyruvate Metabolism Valine, Leucine, and Isoleucine Degradation Tryptophan Metabolism Pyruvate Metabolism Fatty Acid Metabolism Endoplasmic Reticulum Peroxisome Peroxisome