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Endoplasmic Reticulum
3-ketoacyl-CoA
thiolase,
peroxisomal
Hydroxymethylglutaryl-
CoA synthase
mevalonate
kinase
Phosphomevalonate
kinase
Diphosphomevalonate
decarboxylase
Isopentenyl-
diphosphate
Delta-isomerase
Squalene
monooxygenase
Lanosterol
synthase
Delta(24)-
sterol
reductase
Lanosterol
14-alpha
demethylase
Delta(14)-
sterol
reductase
3-hydroxy-3-
methylglutaryl-
coenzyme A
reductase 1
3-hydroxy-3-
methylglutaryl-
coenzyme A
reductase 2
C-4 sterol
methyl oxidase
Methylsterol
monooxygenase
Methylsterol
monooxygenase
C-3 sterol
dehydrogenase
3-keto sterol
reductase
Methylsterol
monooxygenase
Methylsterol
monooxygenase
Methylsterol
monooxygenase
C-3 sterol
dehydrogenase
3-keto sterol
reductase
Sterol 24-C-
methyltransferase
C-8 sterol
isomerase
C-5 sterol
desaturase
C-22 sterol
desaturase
C-24 sterol
reductase
Geranylgeranyl
pyrophosphate
synthase BTS1
Geranylgeranyl
pyrophosphate
synthase BTS1
Squalene
synthase
Farnesyl
pyrophosphate
synthase
Farnesyl
pyrophosphate
synthase
Acetoacetyl-CoA
Acetyl-CoA
CoA
H
2
O
3-Hydroxy-3-methylglutaryl-CoA
CoA
Mevalonic acid
ATP
Mevalonic acid-5P
ADP
ATP
ADP
(R)-5-Diphosphomevalonic acid
ATP
ADP
P
i
Isopentenyl pyrophosphate
CO
2
Dimethylallylpyrophosphate
Squalene
O
2
NADPH
(S)-2,3-Epoxysqualene
H
2
O
NADP
Lanosterol
NADPH
24,25-Dihydrolanosterol
NADP
O
2
NADPH
4,4-Dimethylcholesta-
8,14,24-trienol
Formic acid
NADP
H
2
O
NADPH
4,4-Dimethyl-5a-cholesta-
8,24-dien-3-b-ol
NADP
NADPH
NADP
CoA
H
+
O
2
NADPH
4α-hydroxymethyl-4β-methyl-
5α-cholesta-8,24-dien-3β-ol
NADP
H
2
O
H
+
O
2
NADPH
4α-formyl-4β-methyl-5α-
cholesta-8,24-dien-3β-ol
H
2
O
NADP
O
2
NADPH
4β-methyl-4α-carboxy-
cholesta-8,24-dien-3β-ol
H
2
O
NADP
NADP
3-Keto-4-methylzymosterol
CO
2
NADPH
NADPH
H
+
NADP
4a-Methylzymosterol
H
+
O
2
NADPH
H
2
O
NADP
4α-hydroxymethyl-5α-
cholesta-8,24-dien-3β-ol
H
+
O
2
NADPH
4α-formyl-5α-cholesta-8,24-
dien-3β-ol
H
2
O
NADP
O
2
NADPH
4α-carboxy-5α-cholesta-8,24-
dien-3β-ol
H
2
O
NADP
NADP
5α-cholesta-8,24-dien-3-one
CO
2
NADPH
NADPH
H
+
Zymosterol
NADP
S-Adenosylmethionine
fecosterol
S-Adenosylhomocysteine
H
+
Episterol
H
+
O
2
ferrocytochrome c
5,7,24(28)-Ergostatrienol
H
2
O
ferricytochrome c
H
+
NADPH
O
2
ergosta-5,7,22,24(28)-
tetraen-3-β-ol
NADP
H
2
O
H
+
NADPH
Ergosterol
NADP
Geranyl-PP
PP
i
Farnesyl pyrophosphate
PP
i
NADPH
NADP
PP
i
Magnesium
Magnesium
Magnesium
Magnesium
Butyrate
Metabolism
Pyruvate
Metabolism
Valine,
Leucine, and
Isoleucine
Degradation
Tryptophan
Metabolism
Pyruvate
Metabolism
Fatty Acid
Metabolism
Endoplasmic Reticulum
Peroxisome
Peroxisome