PathBank

Pathway Description

Ketone Body Metabolism

Saccharomyces cerevisiae

Category:

Metabolite Pathway

Sub-Category:

Metabolic

Created: 2016-02-25

Last Updated: 2019-08-14

The ketone body metabolism is a simple pathway that shows a reversible reaction from acetoacetyl-Coa to acetyl-CoA. Both are combined to form S-3-hydroxy-3-methylglutaryl-CoA. The latter compound can then be incorporated into the steroid biosynthesis pathway.

References

Ketone Body Metabolism References

RUDNEY H: The biosynthesis of beta-hydroxy-beta-methylglutaric acid. J Biol Chem. 1957 Jul;227(1):363-77.

Pubmed: 13449080

Bowman S, Churcher C, Badcock K, Brown D, Chillingworth T, Connor R, Dedman K, Devlin K, Gentles S, Hamlin N, Hunt S, Jagels K, Lye G, Moule S, Odell C, Pearson D, Rajandream M, Rice P, Skelton J, Walsh S, Whitehead S, Barrell B: The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII. Nature. 1997 May 29;387(6632 Suppl):90-3.

Pubmed: 9169872

Engel SR, Dietrich FS, Fisk DG, Binkley G, Balakrishnan R, Costanzo MC, Dwight SS, Hitz BC, Karra K, Nash RS, Weng S, Wong ED, Lloyd P, Skrzypek MS, Miyasato SR, Simison M, Cherry JM: The reference genome sequence of Saccharomyces cerevisiae: then and now. G3 (Bethesda). 2014 Mar 20;4(3):389-98. doi: 10.1534/g3.113.008995.

Pubmed: 24374639

Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, O'Shea EK, Weissman JS: Global analysis of protein expression in yeast. Nature. 2003 Oct 16;425(6959):737-41. doi: 10.1038/nature02046.

Pubmed: 14562106

Highlighted elements will appear in red.

Highlight Compounds

	3-Hydroxy-3-methylglutaryl-CoA
	Acetoacetyl-CoA
	Acetone
	Acetyl-CoA
	Coenzyme A
	Water

Highlight Proteins

	Hydroxymethylglutaryl-CoA synthase
	Unknown

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