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Pathway Description
Vitamin B6
Saccharomyces cerevisiae
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2016-02-29
Last Updated: 2025-01-25
Vitamin B6 belongs to the vitamin B complex group and is water-soluble. The active form is Pyridoxal phosphate (PLP) which acts as a cofactor for various essential enzymes in reactions including: amino acid metabolism, transamination, deamination, and decarboxylation. Other forms of the vitamin include: pyridoxine (PN), pyridoxine 5’-phosphate (PNP), pyridoxal (PL), pyridoxamine (PM), pyridoxamine 5’-phosphate (PMP), and 4-pyridoxic acid (PA). Most animals are unable to synthesize the vitamin while most bacteria are able too. Some organisms also import the vitamin to supplement or augment biosynthesis. S. cerevisiae has transporter Tpn1p on the plasma membrane to import vitamin B6. It transports mostly PN, a precursor of PLP, but also PM and PL. Vitamin B6 is also an antioxidant to provide protection against reactive oxygen species. It has been shown that vitamin B6 synthesis is increased in response to cell stress.
References
Vitamin B6 References
Dong YX, Sueda S, Nikawa J, Kondo H: Characterization of the products of the genes SNO1 and SNZ1 involved in pyridoxine synthesis in Saccharomyces cerevisiae. Eur J Biochem. 2004 Feb;271(4):745-52.
Pubmed: 14764090
Garrido-Franco M: Pyridoxine 5'-phosphate synthase: de novo synthesis of vitamin B6 and beyond. Biochim Biophys Acta. 2003 Apr 11;1647(1-2):92-7.
Pubmed: 12686115
Loubbardi A, Marcireau C, Karst F, Guilloton M: Sterol uptake induced by an impairment of pyridoxal phosphate synthesis in Saccharomyces cerevisiae: cloning and sequencing of the PDX3 gene encoding pyridoxine (pyridoxamine) phosphate oxidase. J Bacteriol. 1995 Apr;177(7):1817-23.
Pubmed: 7896706
Stolz J, Vielreicher M: Tpn1p, the plasma membrane vitamin B6 transporter of Saccharomyces cerevisiae. J Biol Chem. 2003 May 23;278(21):18990-6. doi: 10.1074/jbc.M300949200. Epub 2003 Mar 20.
Pubmed: 12649274
Tsuge H, Ozeki K, Ohashi K: Molecular and Enzymatic Properties of Pyridoxamine (Pyridoxine) 5′-Phosphate Oxidase from Baker’s Yeast. Agricultural And Biological Chemistry. 1980 Oct 01;44(10):2329-2335. doi: 10.1080/00021369.1980.10864322.
Mooney S, Leuendorf JE, Hendrickson C, Hellmann H: Vitamin B6: a long known compound of surprising complexity. Molecules. 2009 Jan 12;14(1):329-51. doi: 10.3390/molecules14010329.
Pubmed: 19145213
Holland JP, Labieniec L, Swimmer C, Holland MJ: Homologous nucleotide sequences at the 5' termini of messenger RNAs synthesized from the yeast enolase and glyceraldehyde-3-phosphate dehydrogenase gene families. The primary structure of a third yeast glyceraldehyde-3-phosphate dehydrogenase gene. J Biol Chem. 1983 Apr 25;258(8):5291-9.
Pubmed: 6833300
Galibert F, Alexandraki D, Baur A, Boles E, Chalwatzis N, Chuat JC, Coster F, Cziepluch C, De Haan M, Domdey H, Durand P, Entian KD, Gatius M, Goffeau A, Grivell LA, Hennemann A, Herbert CJ, Heumann K, Hilger F, Hollenberg CP, Huang ME, Jacq C, Jauniaux JC, Katsoulou C, Karpfinger-Hartl L, et al.: Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X. EMBO J. 1996 May 1;15(9):2031-49.
Pubmed: 8641269
Engel SR, Dietrich FS, Fisk DG, Binkley G, Balakrishnan R, Costanzo MC, Dwight SS, Hitz BC, Karra K, Nash RS, Weng S, Wong ED, Lloyd P, Skrzypek MS, Miyasato SR, Simison M, Cherry JM: The reference genome sequence of Saccharomyces cerevisiae: then and now. G3 (Bethesda). 2014 Mar 20;4(3):389-98. doi: 10.1534/g3.113.008995.
Pubmed: 24374639
Nijkamp JF, van den Broek M, Datema E, de Kok S, Bosman L, Luttik MA, Daran-Lapujade P, Vongsangnak W, Nielsen J, Heijne WH, Klaassen P, Paddon CJ, Platt D, Kotter P, van Ham RC, Reinders MJ, Pronk JT, de Ridder D, Daran JM: De novo sequencing, assembly and analysis of the genome of the laboratory strain Saccharomyces cerevisiae CEN.PK113-7D, a model for modern industrial biotechnology. Microb Cell Fact. 2012 Mar 26;11:36. doi: 10.1186/1475-2859-11-36.
Pubmed: 22448915
Overkamp KM, Kotter P, van der Hoek R, Schoondermark-Stolk S, Luttik MA, van Dijken JP, Pronk JT: Functional analysis of structural genes for NAD(+)-dependent formate dehydrogenase in Saccharomyces cerevisiae. Yeast. 2002 Apr;19(6):509-20. doi: 10.1002/yea.856.
Pubmed: 11921099
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