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Pathway Description
Isoleucine Degradation
Saccharomyces cerevisiae
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2016-02-29
Last Updated: 2025-01-25
The degradation of isoleucine starts either in the mitochondria or the cytosol. L-isoleucine reacts with 2-oxoglutarate through a branch-chain amino acid aminotransferase resulting in the release of L-glutamate and 3-methyl-2-oxopentanoate. The latter compound reacts with 2-oxoisovalerate carboxy-lyase resulting in the release of carbon dioxide and methylbutanal. Methylbutanal can then be turned into methylbutanol through a alcohol dehydrogenase
References
Isoleucine Degradation References
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Pubmed: 10989445
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Pubmed: 8091229
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Pubmed: 10338141
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Pubmed: 1574125
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Pubmed: 12554944
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