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Pathway Description
Ether Lipid Metabolism
Saccharomyces cerevisiae
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2016-03-01
Last Updated: 2019-08-14
The metabolism of ether lipids can begin with 1-O-Hexadecyl-2-O-acetyl-sn-glycerol and citicoline reacting through a CPT1 resulting in the release of CMP, 2-acetyl-1-alkyl-sn-glycerol-3-phosphocholine (PAF), in this case, a 2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine. The latter compound reacts with a cytidine monophosphate through a platelet-activating factor acetylhydrolase IB subunit alpha resulting in the release of acetic acid, hydrogen ion and lysoPAF. The latter compound can react with a palmitic acid reacting with TAG lipase / steryl ester hydrolase / phospholipase A2 / LPA acyltransferase resulting in the release of water and 1-O-Palmityl-2-palmitoyl-rac-glycero-3-phosphocholine. The latter compound can also be generated by 1-O-Hexadecyl-2-palmitoyl-sn-glycerol reacting with citicoline through a diacylglycerol cholinephosphotransferase resulting in the release of 1-O-Palmityl-2-palmitoyl-rac-glycero-3-phosphocholine and Cytidine monophosphate. 1-O-Hexadecyl-2-palmitoyl-sn-glycerol reacts with CDP-Ethanolamine through a bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase resulting in the release of 1-hexadecyl-2-palmitoyl-glycero-3-phosphoethanolamine and Cytidine monophosphate
References
Ether Lipid Metabolism References
Kanehisa M, Sato Y, Kawashima M, Furumichi M, Tanabe M: KEGG as a reference resource for gene and protein annotation. Nucleic Acids Res. 2016 Jan 4;44(D1):D457-62. doi: 10.1093/nar/gkv1070. Epub 2015 Oct 17.
Pubmed: 26476454
Kanehisa M, Goto S: KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 2000 Jan 1;28(1):27-30.
Pubmed: 10592173
Hjelmstad RH, Bell RM: The sn-1,2-diacylglycerol cholinephosphotransferase of Saccharomyces cerevisiae. Nucleotide sequence, transcriptional mapping, and gene product analysis of the CPT1 gene. J Biol Chem. 1990 Jan 25;265(3):1755-64.
Pubmed: 2153142
Mallet L, Bussereau F, Jacquet M: A 43.5 kb segment of yeast chromosome XIV, which contains MFA2, MEP2, CAP/SRV2, NAM9, FKB1/FPR1/RBP1, MOM22 and CPT1, predicts an adenosine deaminase gene and 14 new open reading frames. Yeast. 1995 Sep 30;11(12):1195-209. doi: 10.1002/yea.320111210.
Pubmed: 8619318
Hjelmstad RH, Bell RM: sn-1,2-diacylglycerol choline- and ethanolaminephosphotransferases in Saccharomyces cerevisiae. Mixed micellar analysis of the CPT1 and EPT1 gene products. J Biol Chem. 1991 Mar 5;266(7):4357-65.
Pubmed: 1847919
Poirey R, Jauniaux JC: Sequencing analysis of a 36.8 kb fragment of yeast chromosome XV reveals 26 open reading frames including SEC63, CDC31, SUG2, GCD1, RBL2, PNT1, PAC1 and VPH1. Yeast. 1997 Apr;13(5):483-7. doi: 10.1002/(SICI)1097-0061(199704)13:5<483::AID-YEA105>3.0.CO;2-U.
Pubmed: 9153759
Geiser JR, Schott EJ, Kingsbury TJ, Cole NB, Totis LJ, Bhattacharyya G, He L, Hoyt MA: Saccharomyces cerevisiae genes required in the absence of the CIN8-encoded spindle motor act in functionally diverse mitotic pathways. Mol Biol Cell. 1997 Jun;8(6):1035-50. doi: 10.1091/mbc.8.6.1035.
Pubmed: 9201714
Cheret G, Bernardi A, Sor F: DNA sequence analysis of the VPH1-SNF2 region on chromosome XV of Saccharomyces cerevisiae. Yeast. 1996 Sep;12(10B Suppl):1059-64. doi: 10.1002/(SICI)1097-0061(199609)12:10B%3C1059::AID-YEA994%3E3.0.CO;2-7.
Pubmed: 8896271
Garcia-Cantalejo J, Baladron V, Esteban PF, Santos MA, Bou G, Remacha MA, Revuelta JL, Ballesta JP, Jimenez A, del Rey F: The complete sequence of an 18,002 bp segment of Saccharomyces cerevisiae chromosome XI contains the HBS1, MRP-L20 and PRP16 genes, and six new open reading frames. Yeast. 1994 Feb;10(2):231-45. doi: 10.1002/yea.320100210.
Pubmed: 8203164
Dujon B, Alexandraki D, Andre B, Ansorge W, Baladron V, Ballesta JP, Banrevi A, Bolle PA, Bolotin-Fukuhara M, Bossier P, Bou G, Boyer J, Bultrago MJ, Cheret G, Colleaux L, Dalgnan-Fornler B, del Rey F, Dlon C, Domdey H, Dusterhoft A, Dusterhus S, Entlan KD, Erfle H, Esteban PF, Feldmann H, Fernandes L, Robo GM, Fritz C, Fukuhara H, Gabel C, Gaillon L, Carcia-Cantalejo JM, Garcia-Ramirez JJ, Gent NE, Ghazvini M, Goffeau A, Gonzalez A, Grothues D, Guerreiro P, Hegemann J, Hewitt N, Hilger F, Hollenberg CP, Horaitis O, Indge KJ, Jacquier A, James CM, Jauniaux C, Jimenez A, Keuchel H, Kirchrath L, Kleine K, Kotter P, Legrain P, Liebl S, Louis EJ, Maia e Silva A, Marck C, Monnier AL, Mostl D, Muller S, Obermaier B, Oliver SG, Pallier C, Pascolo S, Pfeiffer F, Philippsen P, Planta RJ, Pohl FM, Pohl TM, Pohlmann R, Portetelle D, Purnelle B, Puzos V, Ramezani Rad M, Rasmussen SW, Remacha M, Revuelta JL, Richard GF, Rieger M, Rodrigues-Pousada C, Rose M, Rupp T, Santos MA, Schwager C, Sensen C, Skala J, Soares H, Sor F, Stegemann J, Tettelin H, Thierry A, Tzermia M, Urrestarazu LA, van Dyck L, Van Vliet-Reedijk JC, Valens M, Vandenbo M, Vilela C, Vissers S, von Wettstein D, Voss H, Wiemann S, Xu G, Zimmermann J, Haasemann M, Becker I, Mewes HW: Complete DNA sequence of yeast chromosome XI. Nature. 1994 Jun 2;369(6479):371-8. doi: 10.1038/369371a0.
Pubmed: 8196765
Engel SR, Dietrich FS, Fisk DG, Binkley G, Balakrishnan R, Costanzo MC, Dwight SS, Hitz BC, Karra K, Nash RS, Weng S, Wong ED, Lloyd P, Skrzypek MS, Miyasato SR, Simison M, Cherry JM: The reference genome sequence of Saccharomyces cerevisiae: then and now. G3 (Bethesda). 2014 Mar 20;4(3):389-98. doi: 10.1534/g3.113.008995.
Pubmed: 24374639
Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigo R, Gladyshev VN: Characterization of mammalian selenoproteomes. Science. 2003 May 30;300(5624):1439-43. doi: 10.1126/science.1083516.
Pubmed: 12775843
Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O: Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 2000 Dec 31;7(6):347-55. doi: 10.1093/dnares/7.6.347.
Pubmed: 11214970
Horibata Y, Hirabayashi Y: Identification and characterization of human ethanolaminephosphotransferase1. J Lipid Res. 2007 Mar;48(3):503-8. doi: 10.1194/jlr.C600019-JLR200. Epub 2006 Nov 28.
Pubmed: 17132865
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