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Pathway Description
Inositol Phosphate Metabolism
Saccharomyces cerevisiae
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2016-03-04
Last Updated: 2019-08-14
Inositol phosphates are a group of molecules that are important for a number of cellular functions, such as cell growth, apoptosis, cell migration, endocytosis, and cell differentiation. Inositol phsosphates consist of an inositol (a sixfold alcohol of cyclohexane) phosphorylated at one or more positions. There are a number of different inositol phosphates found in eukaryotes, distinguishable by the number and position of the phosphate groups. Inositol phosphate can be formed either as a product of phosphatidylinositol phosphate metabolism or from glucose 6-phosphate via the enzyme inositol-3-phosphate synthase 1. Conversion between the different types of inositol phosphates then occurs via a number of specific inositol phosphate kinases and phosphatases, which add (kinase) or remove (phosphatase) phosphate groups. The differing roles of the numerous inositol phosphates means that their metabolism must be tightly regulated. This is done via the localization and activation/deactivation of the various kinases and phosphatases, which can be found in the cytoplasm, nucleus or endoplasmic reticulum. The unphosphorylated inositol ring can be used to produce phosphoinositides through phosphatidylinositol phosphate metabolism.
References
Inositol Phosphate Metabolism References
Bennett M, Onnebo SM, Azevedo C, Saiardi A: Inositol pyrophosphates: metabolism and signaling. Cell Mol Life Sci. 2006 Mar;63(5):552-64. doi: 10.1007/s00018-005-5446-z.
Pubmed: 16429326
Dubois E, Scherens B, Vierendeels F, Ho MM, Messenguy F, Shears SB: In Saccharomyces cerevisiae, the inositol polyphosphate kinase activity of Kcs1p is required for resistance to salt stress, cell wall integrity, and vacuolar morphogenesis. J Biol Chem. 2002 Jun 28;277(26):23755-63. doi: 10.1074/jbc.M202206200. Epub 2002 Apr 15.
Pubmed: 11956213
Luo HR, Saiardi A, Yu H, Nagata E, Ye K, Snyder SH: Inositol pyrophosphates are required for DNA hyperrecombination in protein kinase c1 mutant yeast. Biochemistry. 2002 Feb 26;41(8):2509-15.
Pubmed: 11851397
Saiardi A, Caffrey JJ, Snyder SH, Shears SB: The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis. J Biol Chem. 2000 Aug 11;275(32):24686-92. doi: 10.1074/jbc.M002750200.
Pubmed: 10827188
Dubois E, Bercy J, Messenguy F: Characterization of two genes, ARGRI and ARGRIII required for specific regulation of arginine metabolism in yeast. Mol Gen Genet. 1987 Apr;207(1):142-8. doi: 10.1007/bf00331501.
Pubmed: 3298999
Jacq C, Alt-Morbe J, Andre B, Arnold W, Bahr A, Ballesta JP, Bargues M, Baron L, Becker A, Biteau N, Blocker H, Blugeon C, Boskovic J, Brandt P, Bruckner M, Buitrago MJ, Coster F, Delaveau T, del Rey F, Dujon B, Eide LG, Garcia-Cantalejo JM, Goffeau A, Gomez-Peris A, Zaccaria P, et al.: The nucleotide sequence of Saccharomyces cerevisiae chromosome IV. Nature. 1997 May 29;387(6632 Suppl):75-8.
Pubmed: 9169867
Engel SR, Dietrich FS, Fisk DG, Binkley G, Balakrishnan R, Costanzo MC, Dwight SS, Hitz BC, Karra K, Nash RS, Weng S, Wong ED, Lloyd P, Skrzypek MS, Miyasato SR, Simison M, Cherry JM: The reference genome sequence of Saccharomyces cerevisiae: then and now. G3 (Bethesda). 2014 Mar 20;4(3):389-98. doi: 10.1534/g3.113.008995.
Pubmed: 24374639
Stolz LE, Huynh CV, Thorner J, York JD: Identification and characterization of an essential family of inositol polyphosphate 5-phosphatases (INP51, INP52 and INP53 gene products) in the yeast Saccharomyces cerevisiae. Genetics. 1998 Apr;148(4):1715-29.
Pubmed: 9560389
Morales-Johansson H, Jenoe P, Cooke FT, Hall MN: Negative regulation of phosphatidylinositol 4,5-bisphosphate levels by the INP51-associated proteins TAX4 and IRS4. J Biol Chem. 2004 Sep 17;279(38):39604-10. doi: 10.1074/jbc.M405589200. Epub 2004 Jul 20.
Pubmed: 15265867
Voss H, Tamames J, Teodoru C, Valencia A, Sensen C, Wiemann S, Schwager C, Zimmermann J, Sander C, Ansorge W: Nucleotide sequence and analysis of the centromeric region of yeast chromosome IX. Yeast. 1995 Jan;11(1):61-78. doi: 10.1002/yea.320110109.
Pubmed: 7762303
Johnston M, Andrews S, Brinkman R, Cooper J, Ding H, Dover J, Du Z, Favello A, Fulton L, Gattung S, et al.: Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII. Science. 1994 Sep 30;265(5181):2077-82. doi: 10.1126/science.8091229.
Pubmed: 8091229
Lopez F, Leube M, Gil-Mascarell R, Navarro-Avino JP, Serrano R: The yeast inositol monophosphatase is a lithium- and sodium-sensitive enzyme encoded by a non-essential gene pair. Mol Microbiol. 1999 Feb;31(4):1255-64. doi: 10.1046/j.1365-2958.1999.01267.x.
Pubmed: 10096091
York JD, Odom AR, Murphy R, Ives EB, Wente SR: A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export. Science. 1999 Jul 2;285(5424):96-100. doi: 10.1126/science.285.5424.96.
Pubmed: 10390371
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