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Pathway Description
Inositol Metabolism
Saccharomyces cerevisiae
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2016-03-07
Last Updated: 2024-11-18
Inositol (also known as myo-inositol) is a carbocyclic polyol that can be found in many food such as nuts and beans. Inositol (e.g. inositol phosphates, etc.) can act as secondary messengers in eukaryotic cells. Inositol can be synthesized from three resources: inositol monophosphatase 1 can catalyze D-Myo-inositol 4-phosphate, myo-inositol 1-phosphate and 1D-myo-Inositol 3-phosphate to form inositol with water as cofactor.
References
Inositol Metabolism References
Strahl T, Thorner J: Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae. Biochim Biophys Acta. 2007 Mar;1771(3):353-404. doi: 10.1016/j.bbalip.2007.01.015. Epub 2007 Feb 6.
Pubmed: 17382260
Garcia-Bustos JF, Marini F, Stevenson I, Frei C, Hall MN: PIK1, an essential phosphatidylinositol 4-kinase associated with the yeast nucleus. EMBO J. 1994 May 15;13(10):2352-61.
Pubmed: 8194527
Guo S, Stolz LE, Lemrow SM, York JD: SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases. J Biol Chem. 1999 May 7;274(19):12990-5.
Pubmed: 10224048
Han GS, Audhya A, Markley DJ, Emr SD, Carman GM: The Saccharomyces cerevisiae LSB6 gene encodes phosphatidylinositol 4-kinase activity. J Biol Chem. 2002 Dec 6;277(49):47709-18. doi: 10.1074/jbc.M207996200. Epub 2002 Oct 1.
Pubmed: 12361950
Stack JH, Emr SD: Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities. J Biol Chem. 1994 Dec 16;269(50):31552-62.
Pubmed: 7989323
Yoshida S, Ohya Y, Goebl M, Nakano A, Anraku Y: A novel gene, STT4, encodes a phosphatidylinositol 4-kinase in the PKC1 protein kinase pathway of Saccharomyces cerevisiae. J Biol Chem. 1994 Jan 14;269(2):1166-72.
Pubmed: 8288577
Stolz LE, Huynh CV, Thorner J, York JD: Identification and characterization of an essential family of inositol polyphosphate 5-phosphatases (INP51, INP52 and INP53 gene products) in the yeast Saccharomyces cerevisiae. Genetics. 1998 Apr;148(4):1715-29.
Pubmed: 9560389
Morales-Johansson H, Jenoe P, Cooke FT, Hall MN: Negative regulation of phosphatidylinositol 4,5-bisphosphate levels by the INP51-associated proteins TAX4 and IRS4. J Biol Chem. 2004 Sep 17;279(38):39604-10. doi: 10.1074/jbc.M405589200. Epub 2004 Jul 20.
Pubmed: 15265867
Voss H, Tamames J, Teodoru C, Valencia A, Sensen C, Wiemann S, Schwager C, Zimmermann J, Sander C, Ansorge W: Nucleotide sequence and analysis of the centromeric region of yeast chromosome IX. Yeast. 1995 Jan;11(1):61-78. doi: 10.1002/yea.320110109.
Pubmed: 7762303
Johnston M, Andrews S, Brinkman R, Cooper J, Ding H, Dover J, Du Z, Favello A, Fulton L, Gattung S, et al.: Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII. Science. 1994 Sep 30;265(5181):2077-82. doi: 10.1126/science.8091229.
Pubmed: 8091229
Engel SR, Dietrich FS, Fisk DG, Binkley G, Balakrishnan R, Costanzo MC, Dwight SS, Hitz BC, Karra K, Nash RS, Weng S, Wong ED, Lloyd P, Skrzypek MS, Miyasato SR, Simison M, Cherry JM: The reference genome sequence of Saccharomyces cerevisiae: then and now. G3 (Bethesda). 2014 Mar 20;4(3):389-98. doi: 10.1534/g3.113.008995.
Pubmed: 24374639
Lopez F, Leube M, Gil-Mascarell R, Navarro-Avino JP, Serrano R: The yeast inositol monophosphatase is a lithium- and sodium-sensitive enzyme encoded by a non-essential gene pair. Mol Microbiol. 1999 Feb;31(4):1255-64. doi: 10.1046/j.1365-2958.1999.01267.x.
Pubmed: 10096091
Yoko-o T, Matsui Y, Yagisawa H, Nojima H, Uno I, Toh-e A: The putative phosphoinositide-specific phospholipase C gene, PLC1, of the yeast Saccharomyces cerevisiae is important for cell growth. Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1804-8. doi: 10.1073/pnas.90.5.1804.
Pubmed: 8383328
Payne WE, Fitzgerald-Hayes M: A mutation in PLC1, a candidate phosphoinositide-specific phospholipase C gene from Saccharomyces cerevisiae, causes aberrant mitotic chromosome segregation. Mol Cell Biol. 1993 Jul;13(7):4351-64. doi: 10.1128/mcb.13.7.4351.
Pubmed: 8391635
Flick JS, Thorner J: Genetic and biochemical characterization of a phosphatidylinositol-specific phospholipase C in Saccharomyces cerevisiae. Mol Cell Biol. 1993 Sep;13(9):5861-76. doi: 10.1128/mcb.13.9.5861.
Pubmed: 8395015
Yamamoto A, DeWald DB, Boronenkov IV, Anderson RA, Emr SD, Koshland D: Novel PI(4)P 5-kinase homologue, Fab1p, essential for normal vacuole function and morphology in yeast. Mol Biol Cell. 1995 May;6(5):525-39. doi: 10.1091/mbc.6.5.525.
Pubmed: 7663021
Murakami Y, Naitou M, Hagiwara H, Shibata T, Ozawa M, Sasanuma S, Sasanuma M, Tsuchiya Y, Soeda E, Yokoyama K, et al.: Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae. Nat Genet. 1995 Jul;10(3):261-8. doi: 10.1038/ng0795-261.
Pubmed: 7670463
Guo S, Stolz LE, Lemrow SM, York JD: SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases. J Biol Chem. 1999 May 7;274(19):12990-5. doi: 10.1074/jbc.274.19.12990.
Pubmed: 10224048
Philippsen P, Kleine K, Pohlmann R, Dusterhoft A, Hamberg K, Hegemann JH, Obermaier B, Urrestarazu LA, Aert R, Albermann K, Altmann R, Andre B, Baladron V, Ballesta JP, Becam AM, Beinhauer J, Boskovic J, Buitrago MJ, Bussereau F, Coster F, Crouzet M, D'Angelo M, Dal Pero F, De Antoni A, Del Rey F, Doignon F, Domdey H, Dubois E, Fiedler T, Fleig U, Floeth M, Fritz C, Gaillardin C, Garcia-Cantalejo JM, Glansdorff NN, Goffeau A, Gueldener U, Herbert C, Heumann K, Heuss-Neitzel D, Hilbert H, Hinni K, Iraqui Houssaini I, Jacquet M, Jimenez A, Jonniaux JL, Karpfinger L, Lanfranchi G, Lepingle A, Levesque H, Lyck R, Maftahi M, Mallet L, Maurer KC, Messenguy F, Mewes HW, Mosti D, Nasr F, Nicaud JM, Niedenthal RK, Pandolfo D, Pierard A, Piravandi E, Planta RJ, Pohl TM, Purnelle B, Rebischung C, Remacha M, Revuelta JL, Rinke M, Saiz JE, Sartorello F, Scherens B, Sen-Gupta M, Soler-Mira A, Urbanus JH, Valle G, Van Dyck L, Verhasselt P, Vierendeels F, Vissers S, Voet M, Volckaert G, Wach A, Wambutt R, Wedler H, Zollner A, Hani J: The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications. Nature. 1997 May 29;387(6632 Suppl):93-8.
Pubmed: 9169873
Jin N, Chow CY, Liu L, Zolov SN, Bronson R, Davisson M, Petersen JL, Zhang Y, Park S, Duex JE, Goldowitz D, Meisler MH, Weisman LS: VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse. EMBO J. 2008 Dec 17;27(24):3221-34. doi: 10.1038/emboj.2008.248. Epub 2008 Nov 27.
Pubmed: 19037259
Johnston M, Hillier L, Riles L, Albermann K, Andre B, Ansorge W, Benes V, Bruckner M, Delius H, Dubois E, Dusterhoft A, Entian KD, Floeth M, Goffeau A, Hebling U, Heumann K, Heuss-Neitzel D, Hilbert H, Hilger F, Kleine K, Kotter P, Louis EJ, Messenguy F, Mewes HW, Hoheisel JD, et al.: The nucleotide sequence of Saccharomyces cerevisiae chromosome XII. Nature. 1997 May 29;387(6632 Suppl):87-90.
Pubmed: 9169871
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