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Pathway Description
Riboneogenesis
Saccharomyces cerevisiae
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2016-03-30
Last Updated: 2025-01-25
The riboneogenesis pathway is in charge of converting 3 carbon units into ribose. This pathway involves the conversion of fructose 6 phosphate which can be derived from the gluconeogenesis pathway. Fructose 6 phosphate reacts with a glyceraldehyde 3 phosphate through a transketolase resulting in the release of erythrose 4 phosphate and xylulose 5 phosphate. Erythrose 4 phosphate reacts with a dihydroxyacetone phosphate resulting in a release of sedoheptulose 1,7-biphosphate. Sedoheptulose 1,7-biphosphate is transformed by SHB17 resulting in the release of sedoheptulose 7 phosphate and a phosphate. Sedoheptulose 7 phosphate reacts with a glyceraldehyde 3 phosphate through a transketolase resulting in the release of xylulose 5 phosphate and ribose 5 phosphate. Ribose 5 phosphate can react with reversibly through a ribose 5 phosphate ketol-isomerase resulting in the release of ribulose 5 phosphate. Xylulose 5 phosphate can react reversibly through a ribulose 5 phosphate 3-epimerase resulting in the release of ribulose 5 phosphate.
References
Riboneogenesis References
Clasquin MF, Melamud E, Singer A, Gooding JR, Xu X, Dong A, Cui H, Campagna SR, Savchenko A, Yakunin AF, Rabinowitz JD, Caudy AA: Riboneogenesis in yeast. Cell. 2011 Jun 10;145(6):969-80. doi: 10.1016/j.cell.2011.05.022.
Pubmed: 21663798
Sundstrom M, Lindqvist Y, Schneider G, Hellman U, Ronne H: Yeast TKL1 gene encodes a transketolase that is required for efficient glycolysis and biosynthesis of aromatic amino acids. J Biol Chem. 1993 Nov 15;268(32):24346-52.
Pubmed: 8226984
Fletcher TS, Kwee IL, Nakada T, Largman C, Martin BM: DNA sequence of the yeast transketolase gene. Biochemistry. 1992 Feb 18;31(6):1892-6. doi: 10.1021/bi00121a044.
Pubmed: 1737042
Bussey H, Storms RK, Ahmed A, Albermann K, Allen E, Ansorge W, Araujo R, Aparicio A, Barrell B, Badcock K, Benes V, Botstein D, Bowman S, Bruckner M, Carpenter J, Cherry JM, Chung E, Churcher C, Coster F, Davis K, Davis RW, Dietrich FS, Delius H, DiPaolo T, Hani J, et al.: The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI. Nature. 1997 May 29;387(6632 Suppl):103-5.
Pubmed: 9169875
Schaaff-Gerstenschlager I, Mannhaupt G, Vetter I, Zimmermann FK, Feldmann H: TKL2, a second transketolase gene of Saccharomyces cerevisiae. Cloning, sequence and deletion analysis of the gene. Eur J Biochem. 1993 Oct 1;217(1):487-92. doi: 10.1111/j.1432-1033.1993.tb18268.x.
Pubmed: 7916691
Mannhaupt G, Stucka R, Ehnle S, Vetter I, Feldmann H: Analysis of a 70 kb region on the right arm of yeast chromosome II. Yeast. 1994 Oct;10(10):1363-81. doi: 10.1002/yea.320101014.
Pubmed: 7900426
Feldmann H, Aigle M, Aljinovic G, Andre B, Baclet MC, Barthe C, Baur A, Becam AM, Biteau N, Boles E, Brandt T, Brendel M, Bruckner M, Bussereau F, Christiansen C, Contreras R, Crouzet M, Cziepluch C, Demolis N, Delaveau T, Doignon F, Domdey H, Dusterhus S, Dubois E, Dujon B, El Bakkoury M, Entian KD, Feurmann M, Fiers W, Fobo GM, Fritz C, Gassenhuber H, Glandsdorff N, Goffeau A, Grivell LA, de Haan M, Hein C, Herbert CJ, Hollenberg CP, Holmstrom K, Jacq C, Jacquet M, Jauniaux JC, Jonniaux JL, Kallesoe T, Kiesau P, Kirchrath L, Kotter P, Korol S, Liebl S, Logghe M, Lohan AJ, Louis EJ, Li ZY, Maat MJ, Mallet L, Mannhaupt G, Messenguy F, Miosga T, Molemans F, Muller S, Nasr F, Obermaier B, Perea J, Pierard A, Piravandi E, Pohl FM, Pohl TM, Potier S, Proft M, Purnelle B, Ramezani Rad M, Rieger M, Rose M, Schaaff-Gerstenschlager I, Scherens B, Schwarzlose C, Skala J, Slonimski PP, Smits PH, Souciet JL, Steensma HY, Stucka R, Urrestarazu A, van der Aart QJ, van Dyck L, Vassarotti A, Vetter I, Vierendeels F, Vissers S, Wagner G, de Wergifosse P, Wolfe KH, Zagulski M, Zimmermann FK, Mewes HW, Kleine K: Complete DNA sequence of yeast chromosome II. EMBO J. 1994 Dec 15;13(24):5795-809.
Pubmed: 7813418
Dujon B, Alexandraki D, Andre B, Ansorge W, Baladron V, Ballesta JP, Banrevi A, Bolle PA, Bolotin-Fukuhara M, Bossier P, Bou G, Boyer J, Bultrago MJ, Cheret G, Colleaux L, Dalgnan-Fornler B, del Rey F, Dlon C, Domdey H, Dusterhoft A, Dusterhus S, Entlan KD, Erfle H, Esteban PF, Feldmann H, Fernandes L, Robo GM, Fritz C, Fukuhara H, Gabel C, Gaillon L, Carcia-Cantalejo JM, Garcia-Ramirez JJ, Gent NE, Ghazvini M, Goffeau A, Gonzalez A, Grothues D, Guerreiro P, Hegemann J, Hewitt N, Hilger F, Hollenberg CP, Horaitis O, Indge KJ, Jacquier A, James CM, Jauniaux C, Jimenez A, Keuchel H, Kirchrath L, Kleine K, Kotter P, Legrain P, Liebl S, Louis EJ, Maia e Silva A, Marck C, Monnier AL, Mostl D, Muller S, Obermaier B, Oliver SG, Pallier C, Pascolo S, Pfeiffer F, Philippsen P, Planta RJ, Pohl FM, Pohl TM, Pohlmann R, Portetelle D, Purnelle B, Puzos V, Ramezani Rad M, Rasmussen SW, Remacha M, Revuelta JL, Richard GF, Rieger M, Rodrigues-Pousada C, Rose M, Rupp T, Santos MA, Schwager C, Sensen C, Skala J, Soares H, Sor F, Stegemann J, Tettelin H, Thierry A, Tzermia M, Urrestarazu LA, van Dyck L, Van Vliet-Reedijk JC, Valens M, Vandenbo M, Vilela C, Vissers S, von Wettstein D, Voss H, Wiemann S, Xu G, Zimmermann J, Haasemann M, Becker I, Mewes HW: Complete DNA sequence of yeast chromosome XI. Nature. 1994 Jun 2;369(6479):371-8. doi: 10.1038/369371a0.
Pubmed: 8196765
Engel SR, Dietrich FS, Fisk DG, Binkley G, Balakrishnan R, Costanzo MC, Dwight SS, Hitz BC, Karra K, Nash RS, Weng S, Wong ED, Lloyd P, Skrzypek MS, Miyasato SR, Simison M, Cherry JM: The reference genome sequence of Saccharomyces cerevisiae: then and now. G3 (Bethesda). 2014 Mar 20;4(3):389-98. doi: 10.1534/g3.113.008995.
Pubmed: 24374639
Huh WK, Falvo JV, Gerke LC, Carroll AS, Howson RW, Weissman JS, O'Shea EK: Global analysis of protein localization in budding yeast. Nature. 2003 Oct 16;425(6959):686-91. doi: 10.1038/nature02026.
Pubmed: 14562095
Voss H, Benes V, Andrade MA, Valencia A, Rechmann S, Teodoru C, Schwager C, Paces V, Sander C, Ansorge W: DNA sequencing and analysis of 130 kb from yeast chromosome XV. Yeast. 1997 Jun 15;13(7):655-72. doi: 10.1002/(SICI)1097-0061(19970615)13:7<655::AID-YEA120>3.0.CO;2-I.
Pubmed: 9200815
Dujon B, Albermann K, Aldea M, Alexandraki D, Ansorge W, Arino J, Benes V, Bohn C, Bolotin-Fukuhara M, Bordonne R, Boyer J, Camasses A, Casamayor A, Casas C, Cheret G, Cziepluch C, Daignan-Fornier B, Dang DV, de Haan M, Delius H, Durand P, Fairhead C, Feldmann H, Gaillon L, Kleine K, et al.: The nucleotide sequence of Saccharomyces cerevisiae chromosome XV. Nature. 1997 May 29;387(6632 Suppl):98-102.
Pubmed: 9169874
Miosga T, Zimmermann FK: Cloning and characterization of the first two genes of the non-oxidative part of the Saccharomyces cerevisiae pentose-phosphate pathway. Curr Genet. 1996 Nov;30(5):404-9.
Pubmed: 8929392
Juhnke H, Krems B, Kotter P, Entian KD: Mutants that show increased sensitivity to hydrogen peroxide reveal an important role for the pentose phosphate pathway in protection of yeast against oxidative stress. Mol Gen Genet. 1996 Sep 25;252(4):456-64. doi: 10.1007/bf02173011.
Pubmed: 8879247
Cziepluch C, Kordes E, Pujol A, Jauniaux JC: Sequencing analysis of a 40.2 kb fragment of yeast chromosome X reveals 19 open reading frames including URA2 (5' end), TRK1, PBS2, SPT10, GCD14, RPE1, PHO86, NCA3, ASF1, CCT7, GZF3, two tRNA genes, three remnant delta elements and a Ty4 transposon. Yeast. 1996 Nov;12(14):1471-4. doi: 10.1002/(SICI)1097-0061(199611)12:14%3C1471::AID-YEA30%3E3.0.CO;2-4.
Pubmed: 8948101
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