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Pathway Description
TOR Signalling Pathway: Rapamycin-Based Repression
Saccharomyces cerevisiae
Category:
Protein Pathway
Sub-Categories:
Kinase Signaling
Gene Regulatory
Cellular Response
Created: 2016-04-04
Last Updated: 2019-08-16
The TOR signalling pathway is responsible for the cellular reactions towards nutrient and energy availability and hypoxia/stress.
When TOR1/2 is activated, it activates TAP42 which in turn can inhibit SIT4 . I can also activate TAP41 phosphorylation. The enzyme SIT4 activates the dephosphorylation of TIP41 which in turn inhibits TAP42. The enzyme SIT4 also activates the dephosphorylation of Ure2-Gln3 complex and the
separation of Ure2 and Gln3. Gln3 then gets incorporated into the nucleus resulting in the transcription of GLN1, GLT1,GDH1,GDH2,GAP1,MEP2,DAL3,PUT1 which are incorporated into Nitrogen Utilization
References
TOR Signalling Pathway: Rapamycin-Based Repression References
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Pubmed: 10604478
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Pubmed: 8186460
Cafferkey R, Young PR, McLaughlin MM, Bergsma DJ, Koltin Y, Sathe GM, Faucette L, Eng WK, Johnson RK, Livi GP: Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity. Mol Cell Biol. 1993 Oct;13(10):6012-23. doi: 10.1128/mcb.13.10.6012.
Pubmed: 8413204
Huang ME, Manus V, Chuat JC, Galibert F: Analysis of a 62 kb DNA sequence of chromosome X reveals 36 open reading frames and a gene cluster with a counterpart on chromosome XI. Yeast. 1996 Jul;12(9):869-75. doi: 10.1002/(SICI)1097-0061(199607)12:9%3C869::AID-YEA964%3E3.0.CO;2-1.
Pubmed: 8840504
Kunz J, Henriquez R, Schneider U, Deuter-Reinhard M, Movva NR, Hall MN: Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression. Cell. 1993 May 7;73(3):585-96. doi: 10.1016/0092-8674(93)90144-f.
Pubmed: 8387896
Cardenas ME, Heitman J: FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity. EMBO J. 1995 Dec 1;14(23):5892-907.
Pubmed: 8846782
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Pubmed: 8196765
Coschigano PW, Magasanik B: The URE2 gene product of Saccharomyces cerevisiae plays an important role in the cellular response to the nitrogen source and has homology to glutathione s-transferases. Mol Cell Biol. 1991 Feb;11(2):822-32. doi: 10.1128/mcb.11.2.822.
Pubmed: 1990286
Wickner RB: [URE3] as an altered URE2 protein: evidence for a prion analog in Saccharomyces cerevisiae. Science. 1994 Apr 22;264(5158):566-9. doi: 10.1126/science.7909170.
Pubmed: 7909170
Edskes HK, Wickner RB: Conservation of a portion of the S. cerevisiae Ure2p prion domain that interacts with the full-length protein. Proc Natl Acad Sci U S A. 2002 Dec 10;99 Suppl 4:16384-91. doi: 10.1073/pnas.162349599. Epub 2002 Aug 12.
Pubmed: 12177423
Minehart PL, Magasanik B: Sequence and expression of GLN3, a positive nitrogen regulatory gene of Saccharomyces cerevisiae encoding a protein with a putative zinc finger DNA-binding domain. Mol Cell Biol. 1991 Dec;11(12):6216-28. doi: 10.1128/mcb.11.12.6216.
Pubmed: 1682800
Dietrich FS, Mulligan J, Hennessy K, Yelton MA, Allen E, Araujo R, Aviles E, Berno A, Brennan T, Carpenter J, Chen E, Cherry JM, Chung E, Duncan M, Guzman E, Hartzell G, Hunicke-Smith S, Hyman RW, Kayser A, Komp C, Lashkari D, Lew H, Lin D, Mosedale D, Davis RW, et al.: The nucleotide sequence of Saccharomyces cerevisiae chromosome V. Nature. 1997 May 29;387(6632 Suppl):78-81.
Pubmed: 9169868
Engel SR, Dietrich FS, Fisk DG, Binkley G, Balakrishnan R, Costanzo MC, Dwight SS, Hitz BC, Karra K, Nash RS, Weng S, Wong ED, Lloyd P, Skrzypek MS, Miyasato SR, Simison M, Cherry JM: The reference genome sequence of Saccharomyces cerevisiae: then and now. G3 (Bethesda). 2014 Mar 20;4(3):389-98. doi: 10.1534/g3.113.008995.
Pubmed: 24374639
Arndt KT, Styles CA, Fink GR: A suppressor of a HIS4 transcriptional defect encodes a protein with homology to the catalytic subunit of protein phosphatases. Cell. 1989 Feb 24;56(4):527-37. doi: 10.1016/0092-8674(89)90576-x.
Pubmed: 2537149
Jacq C, Alt-Morbe J, Andre B, Arnold W, Bahr A, Ballesta JP, Bargues M, Baron L, Becker A, Biteau N, Blocker H, Blugeon C, Boskovic J, Brandt P, Bruckner M, Buitrago MJ, Coster F, Delaveau T, del Rey F, Dujon B, Eide LG, Garcia-Cantalejo JM, Goffeau A, Gomez-Peris A, Zaccaria P, et al.: The nucleotide sequence of Saccharomyces cerevisiae chromosome IV. Nature. 1997 May 29;387(6632 Suppl):75-8.
Pubmed: 9169867
Di Como CJ, Arndt KT: Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases. Genes Dev. 1996 Aug 1;10(15):1904-16. doi: 10.1101/gad.10.15.1904.
Pubmed: 8756348
Bowman S, Churcher C, Badcock K, Brown D, Chillingworth T, Connor R, Dedman K, Devlin K, Gentles S, Hamlin N, Hunt S, Jagels K, Lye G, Moule S, Odell C, Pearson D, Rajandream M, Rice P, Skelton J, Walsh S, Whitehead S, Barrell B: The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII. Nature. 1997 May 29;387(6632 Suppl):90-3.
Pubmed: 9169872
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