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Pathway Description

Phosphatidylcholine Biosynthesis PC(15:1(9Z)/18:1(9Z))

Saccharomyces cerevisiae

Category:

Metabolite Pathway

Sub-Category:

Metabolic

Created: 2016-07-24

Last Updated: 2025-01-31

Phosphatidyl ethanolamine reacts with S-adenosylmethionine through a phosphatdylethanolamine N-methyltransferase resulting in the release of hydrogen ion and S-adenosylhomocysteine an a PE-NMe. The PE-NMe reacts with S'-adenosylmethionine through a phosphotidyl-N-methylethanolamine N-methyltransferase resulting in the release of hydrogen ion, s-adenosylhomocysteine and PE-NMe2. The PE-NMe2 reacts with s-adenosylmethionine through a phosphotidyl-N-methylethanolamine N-methyltransferase resuilting in the release of hydrogen ion, s-adenosylhomocysteine and PC

References

Phosphatidylcholine Biosynthesis PC(15:1(9Z)/18:1(9Z)) References

Aktas M, Wessel M, Hacker S, Klusener S, Gleichenhagen J, Narberhaus F: Phosphatidylcholine biosynthesis and its significance in bacteria interacting with eukaryotic cells. Eur J Cell Biol. 2010 Dec;89(12):888-94. doi: 10.1016/j.ejcb.2010.06.013. Epub 2010 Jul 24.

Pubmed: 20656373

Bolognese CP, McGraw P: The isolation and characterization in yeast of a gene for Arabidopsis S-adenosylmethionine:phospho-ethanolamine N-methyltransferase. Plant Physiol. 2000 Dec;124(4):1800-13. doi: 10.1104/pp.124.4.1800.

Pubmed: 11115895

Boumann HA, de Kroon AI: The contributions of biosynthesis and acyl chain remodelling to the molecular species profile of phosphatidylcholine in yeast. Biochem Soc Trans. 2005 Nov;33(Pt 5):1146-9. doi: 10.1042/BST20051146.

Pubmed: 16246068

Skala J, Nawrocki A, Goffeau A: The sequence of a 27 kb segment on the right arm of chromosome VII from Saccharomyces cerevisiae reveals MOL1, NAT2, RPL30B, RSR1, CYS4, PEM1/CHO2, NSR1 genes and ten new open reading frames. Yeast. 1995 Nov;11(14):1421-7. doi: 10.1002/yea.320111410.

Pubmed: 8585325

Kodaki T, Yamashita S: Yeast phosphatidylethanolamine methylation pathway. Cloning and characterization of two distinct methyltransferase genes. J Biol Chem. 1987 Nov 15;262(32):15428-35.

Pubmed: 2445736

Tettelin H, Agostoni Carbone ML, Albermann K, Albers M, Arroyo J, Backes U, Barreiros T, Bertani I, Bjourson AJ, Bruckner M, Bruschi CV, Carignani G, Castagnoli L, Cerdan E, Clemente ML, Coblenz A, Coglievina M, Coissac E, Defoor E, Del Bino S, Delius H, Delneri D, de Wergifosse P, Dujon B, Kleine K, et al.: The nucleotide sequence of Saccharomyces cerevisiae chromosome VII. Nature. 1997 May 29;387(6632 Suppl):81-4.

Pubmed: 9169869

Huang ME, Manus V, Chuat JC, Galibert F: Analysis of a 62 kb DNA sequence of chromosome X reveals 36 open reading frames and a gene cluster with a counterpart on chromosome XI. Yeast. 1996 Jul;12(9):869-75. doi: 10.1002/(SICI)1097-0061(199607)12:9%3C869::AID-YEA964%3E3.0.CO;2-1.

Pubmed: 8840504

Galibert F, Alexandraki D, Baur A, Boles E, Chalwatzis N, Chuat JC, Coster F, Cziepluch C, De Haan M, Domdey H, Durand P, Entian KD, Gatius M, Goffeau A, Grivell LA, Hennemann A, Herbert CJ, Heumann K, Hilger F, Hollenberg CP, Huang ME, Jacq C, Jauniaux JC, Katsoulou C, Karpfinger-Hartl L, et al.: Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X. EMBO J. 1996 May 1;15(9):2031-49.

Pubmed: 8641269

This pathway was generated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Generated from SMP0002489

Highlighted elements will appear in red.

Highlight Compounds

	Hydrogen Ion
	PC(15:1(9Z)/15:1(9Z))
	PE(15:1(9Z)/18:1(9Z))
	PE-NMe(15:1(9Z)/18:1(9Z))
	PE-NMe2(15:1(9Z)/18:1(9Z))
	S-Adenosylhomocysteine
	S-Adenosylmethionine

Highlight Proteins

	Phosphatidyl-N-methylethanolamine N-methyltransferase
	Phosphatidylethanolamine N-methyltransferase

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