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Pathway Description
Arginine and Proline Metabolism
Saccharomyces cerevisiae
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2016-11-08
Last Updated: 2025-01-25
Arginine and proline metabolism demonstrates the co-metabolism of arginine, ornithine, proline, citrulline and glutamate in mitochondria. Argininosuccinate synthase catalyzes citrulline into argininosuccinic acid with ATP and L-Aspartic acid. Argininosuccinic acid is cleaved by argininosuccinate lyase to generate L-arginine (arginine), which also generated fumaric acid for citric acid cycle. Citrulline can be generated from ornithine by the ornithine carbamoyltransferase at mitochondria; and ornithine can be generated by series of metabolism that is associated with proline dehydrogenase 1 (with cofactor FAD) and pyrroline-5-carboxylate reductase 2 at mitochondria. Proline is derived from L-glutamatic acid with conversion of L-glutamatic acid to 1-pyrroline-5-carboxylic acid by delta-1-pyrroline-5-carboxylate dehydrogenase and NAD; then 1-pyrroline-5-carboxylic acid can converted to L-proline via proline dehydrogenase 1 with cofactor FAD.
References
Arginine and Proline Metabolism References
Genbauffe FS, Cooper TG: The urea amidolyase (DUR1,2) gene of Saccharomyces cerevisiae. DNA Seq. 1991;2(1):19-32.
Pubmed: 1802034
Feldmann H, Aigle M, Aljinovic G, Andre B, Baclet MC, Barthe C, Baur A, Becam AM, Biteau N, Boles E, Brandt T, Brendel M, Bruckner M, Bussereau F, Christiansen C, Contreras R, Crouzet M, Cziepluch C, Demolis N, Delaveau T, Doignon F, Domdey H, Dusterhus S, Dubois E, Dujon B, El Bakkoury M, Entian KD, Feurmann M, Fiers W, Fobo GM, Fritz C, Gassenhuber H, Glandsdorff N, Goffeau A, Grivell LA, de Haan M, Hein C, Herbert CJ, Hollenberg CP, Holmstrom K, Jacq C, Jacquet M, Jauniaux JC, Jonniaux JL, Kallesoe T, Kiesau P, Kirchrath L, Kotter P, Korol S, Liebl S, Logghe M, Lohan AJ, Louis EJ, Li ZY, Maat MJ, Mallet L, Mannhaupt G, Messenguy F, Miosga T, Molemans F, Muller S, Nasr F, Obermaier B, Perea J, Pierard A, Piravandi E, Pohl FM, Pohl TM, Potier S, Proft M, Purnelle B, Ramezani Rad M, Rieger M, Rose M, Schaaff-Gerstenschlager I, Scherens B, Schwarzlose C, Skala J, Slonimski PP, Smits PH, Souciet JL, Steensma HY, Stucka R, Urrestarazu A, van der Aart QJ, van Dyck L, Vassarotti A, Vetter I, Vierendeels F, Vissers S, Wagner G, de Wergifosse P, Wolfe KH, Zagulski M, Zimmermann FK, Mewes HW, Kleine K: Complete DNA sequence of yeast chromosome II. EMBO J. 1994 Dec 15;13(24):5795-809.
Pubmed: 7813418
Engel SR, Dietrich FS, Fisk DG, Binkley G, Balakrishnan R, Costanzo MC, Dwight SS, Hitz BC, Karra K, Nash RS, Weng S, Wong ED, Lloyd P, Skrzypek MS, Miyasato SR, Simison M, Cherry JM: The reference genome sequence of Saccharomyces cerevisiae: then and now. G3 (Bethesda). 2014 Mar 20;4(3):389-98. doi: 10.1534/g3.113.008995.
Pubmed: 24374639
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