Quantitative metabolomics services for biomarker discovery and validation.
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HMDHP transporter Nudix hydrolase dihydroneopterin phosphate phosphatase HPPK-DHPS HPPK-DHPS dihydroneopterin aldolase 1 dihydroneopterin aldolase 1 dihydroneopterin aldolase 1 GTP cyclohydrolase GTP p-Aminobenzoic acid HMDHP HMDHP Dihydroneopterin triphosphate H2O Dihydroneopterin phosphate PPi H+ H2O 7,8- Dihydroneopterin Pi ATP HMDHP pyrophosphate AMP H+ 7,8- Dihydropteroic acid PPi Glycolaldehyde 7,8- dihydromonapterin H2O Formic acid H+ Magnesium Magnesium Purine Metabolism pABA Synthesis Sub-Pathway Folate Biosynthesis Matrix Outer Mitochondrial Membrane Inner Mitochondrial Membrane Outer Chloroplast Membrane Inner Chloroplast Membrane Stroma Cytosol
Mitochondria Chloroplast ? NUDT1 ? CytHPPK/DHPS CytHPPK/DHPS FOLB1 FOLB1 FOLB1 GCH1 Guanosine triphosphate p-Aminobenzoic acid HMDHP HMDHP Dihydroneopterin triphosphate Water Dihydroneopterin phosphate Pyrophosphate Hydrogen Ion Water 7,8- Dihydroneopterin Phosphate Adenosine triphosphate HMDHP pyrophosphate Adenosine monophosphate Hydrogen Ion 7,8- Dihydropteroic acid Pyrophosphate Glycolaldehyde 7,8- dihydromonapterin Water Formic acid Hydrogen Ion Purine Metabolism pABA Synthesis Sub-Pathway Folate Biosynthesis
? NUDT1 ? CytHPPK/DHPS CytHPPK/DHPS FOLB1 FOLB1 FOLB1 GCH1 GTP p-Amnba HMDHP HMDHP DHNTP H2O DhptPP PPi H+ H2O 7,8DHPN Pi ATP HMDHP-P AMP H+ H2Pte PPi Glyah 78DHmpn H2O Formate H+ Mg2+ Mg2+ Pur Met p S S-P Fol Bio Matrix Outer Mitochondrial Membrane Inner Mitochondrial Membrane Outer Chloroplast Membrane Inner Chloroplast Membrane Stroma Cytosol