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Pathway Description
Methionine Metabolism
Mus musculus
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2018-01-21
Last Updated: 2019-09-15
Methionine metabolism is a process that is necessary for humans. Methionine metabolism in mammals happens within two pathways, a methionine cycle and a transsulfuration sequence. These pathways have three common reactions with both pathways including the transformation of methionine to S-adenosylmethionine (SAM), the use of SAM in many different transmethylation reactions resulting in a methylated product plus S-adenosylhomocysteine, and the conversion of S-adenosylhomocysteine to produce the compounds homocysteine and adenosine. The reactions mentioned above not only produce cysteine, they also create a-ketobutyrate. This compound is then converted to succinyl-CoA through a three step process after being converted to propionyl-CoA. If the amino acids cysteine and methionine are available in enough quantity, the pathway will accumulate SAM and this will in turn encourage the production of cysteine and a-ketobutyrate, which are both glucogenic, through cystathionine synthase. When there is a lack of methionine, there is a decrease in the production of SAM, which limits cystathionine synthase activity.
References
Methionine Metabolism References
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Ishii I, Akahoshi N, Yu XN, Kobayashi Y, Namekata K, Komaki G, Kimura H: Murine cystathionine gamma-lyase: complete cDNA and genomic sequences, promoter activity, tissue distribution and developmental expression. Biochem J. 2004 Jul 1;381(Pt 1):113-23. doi: 10.1042/BJ20040243.
Pubmed: 15038791
Yang G, Wu L, Jiang B, Yang W, Qi J, Cao K, Meng Q, Mustafa AK, Mu W, Zhang S, Snyder SH, Wang R: H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science. 2008 Oct 24;322(5901):587-90. doi: 10.1126/science.1162667.
Pubmed: 18948540
Neece DJ, Griffiths MA, Garrow TA: Isolation and characterization of a mouse betaine-homocysteine S-methyltransferase gene and pseudogene. Gene. 2000 May 30;250(1-2):31-40. doi: 10.1016/s0378-1119(00)00191-8.
Pubmed: 10854776
Aguirre-Arteta AM, Grunewald I, Cardoso MC, Leonhardt H: Expression of an alternative Dnmt1 isoform during muscle differentiation. Cell Growth Differ. 2000 Oct;11(10):551-9.
Pubmed: 11063128
Margot JB, Aguirre-Arteta AM, Di Giacco BV, Pradhan S, Roberts RJ, Cardoso MC, Leonhardt H: Structure and function of the mouse DNA methyltransferase gene: Dnmt1 shows a tripartite structure. J Mol Biol. 2000 Mar 24;297(2):293-300. doi: 10.1006/jmbi.2000.3588.
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Waris T, Ihalainen R, Keranen MR, Pajunen A: Molecular cloning of the mouse S-adenosylmethionine decarboxylase cDNA: specific protein binding to the conserved region of the mRNA 5'-untranslated region. Biochem Biophys Res Commun. 1992 Nov 30;189(1):424-9. doi: 10.1016/0006-291x(92)91575-b.
Pubmed: 1449493
Suzuki T, Sadakata Y, Kashiwagi K, Hoshino K, Kakinuma Y, Shirahata A, Igarashi K: Overproduction of S-adenosylmethionine decarboxylase in ethylglyoxal-bis(guanylhydrazone)-resistant mouse FM3A cells. Eur J Biochem. 1993 Jul 15;215(2):247-53. doi: 10.1111/j.1432-1033.1993.tb18029.x.
Pubmed: 8344293
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Pubmed: 10570962
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000033
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