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Pathway Description
Methylhistidine Metabolism
Mus musculus
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2018-01-21
Last Updated: 2019-09-12
Methylhistidine is a modified amino acid that is produced in myocytes during the methylation of actin and myosin. It is also formed from the methylation of L-histidine, which takes the methyl group from S-adenosylmethionine and forms S-adenosylhomocysteine as a byproduct.
After its formation in the myocytes, methylhistidine enters the blood stream and travels to the kidneys, where it is excreted in the urine.
Methylhistidine is present in the blood and urine in higher concentrations after skeletal muscle protein breakdown, which can occur due to disease or injury. Because of this, it can be used to judge how much muscle breakdown is occurring. Methylhistidine levels are also affected by diet, and may differ between vegetarian diets and those containing meats.
References
Methylhistidine Metabolism References
Wang H, Hu P, Jiang J: Measurement of 1- and 3-methylhistidine in human urine by ultra performance liquid chromatography-tandem mass spectrometry. Clin Chim Acta. 2012 Jan 18;413(1-2):131-8. doi: 10.1016/j.cca.2011.09.007. Epub 2011 Sep 14.
Pubmed: 21945731
Long CL, Haverberg LN, Young VR, Kinney JM, Munro HN, Geiger JW: Metabolism of 3-methylhistidine in man. Metabolism. 1975 Aug;24(8):929-35.
Pubmed: 1143090
Huszar G, Elzinga M: Amino acid sequence around the single 3-methylhistidine residue in rabbit skeletal muscle myosin. Biochemistry. 1971 Jan 19;10(2):229-36.
Pubmed: 5539225
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000715
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