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Pathway Description
Spermidine and Spermine Biosynthesis
Mus musculus
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2018-01-21
Last Updated: 2019-08-16
The Spermidine and Spermine Biosynthesis pathway highlights the creation of these cruicial polyamines. Spermidine and spermine are produced in many tissues, as they are involved in the regulation of genetic processes from DNA synthesis to cell migration, proliferation, differentiation and apoptosis. These positiviely charged amines interact with negatively charged phosphates in nucleic acids to exert their regulatory effects on cellular processes. Spermidine originates from the action of spermidine synthase, which converts the methionine derivative S-adenosylmethionine and the ornithine derivative putrescine into spermidine 5'-methylthioadenosine. Spermidine is subsequently processed into spermine by spermine synthase in the presence of the aminopropyl donor, S-adenosylmethioninamine.
References
Spermidine and Spermine Biosynthesis References
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Pubmed: 16141072
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Pubmed: 21183079
Shima H, Matsumoto M, Ishigami Y, Ebina M, Muto A, Sato Y, Kumagai S, Ochiai K, Suzuki T, Igarashi K: S-Adenosylmethionine Synthesis Is Regulated by Selective N(6)-Adenosine Methylation and mRNA Degradation Involving METTL16 and YTHDC1. Cell Rep. 2017 Dec 19;21(12):3354-3363. doi: 10.1016/j.celrep.2017.11.092.
Pubmed: 29262316
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Pubmed: 16022199
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP: Lineage-specific biology revealed by a finished genome assembly of the mouse. PLoS Biol. 2009 May 5;7(5):e1000112. doi: 10.1371/journal.pbio.1000112. Epub 2009 May 26.
Pubmed: 19468303
Myohanen S, Wahlfors J, Alhonen L, Janne J: Nucleotide sequence of mouse spermidine synthase cDNA. DNA Seq. 1994;4(5):343-6.
Pubmed: 7803821
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Pubmed: 15489334
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Pubmed: 9063736
Gupta M, Coffino P: Mouse ornithine decarboxylase. Complete amino acid sequence deduced from cDNA. J Biol Chem. 1985 Mar 10;260(5):2941-4.
Pubmed: 2982844
Kahana C, Nathans D: Nucleotide sequence of murine ornithine decarboxylase mRNA. Proc Natl Acad Sci U S A. 1985 Mar;82(6):1673-7. doi: 10.1073/pnas.82.6.1673.
Pubmed: 3856848
Coffino P, Chen EL: Nucleotide sequence of the mouse ornithine decarboxylase gene. Nucleic Acids Res. 1988 Mar 25;16(6):2731-2. doi: 10.1093/nar/16.6.2731.
Pubmed: 3362685
Waris T, Ihalainen R, Keranen MR, Pajunen A: Molecular cloning of the mouse S-adenosylmethionine decarboxylase cDNA: specific protein binding to the conserved region of the mRNA 5'-untranslated region. Biochem Biophys Res Commun. 1992 Nov 30;189(1):424-9. doi: 10.1016/0006-291x(92)91575-b.
Pubmed: 1449493
Suzuki T, Sadakata Y, Kashiwagi K, Hoshino K, Kakinuma Y, Shirahata A, Igarashi K: Overproduction of S-adenosylmethionine decarboxylase in ethylglyoxal-bis(guanylhydrazone)-resistant mouse FM3A cells. Eur J Biochem. 1993 Jul 15;215(2):247-53. doi: 10.1111/j.1432-1033.1993.tb18029.x.
Pubmed: 8344293
Nishimura K, Kashiwagi K, Matsuda Y, Janne OA, Igarashi K: Gene structure and chromosomal localization of mouse S-adenosylmethionine decarboxylase. Gene. 1999 Oct 1;238(2):343-50. doi: 10.1016/s0378-1119(99)00355-8.
Pubmed: 10570962
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000445
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