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Pathway Description
Cadmium Induces DNA Synthesis and Proliferation in Macrophages
Homo sapiens
Category:
Protein Pathway
Sub-Categories:
Immunological
Disease
Gene Regulatory
Cellular Response
Created: 2018-07-19
Last Updated: 2019-08-16
Cadmium (Cd(2+)) exposure increases the risk of cancer in humans and animals. Humans may come into contact with cadmium when smoking and ingesting contaminated food. This will increase the risk of lung cancer and prostate cancer. In the millimolar range, cadmium will inhibit cell growth. Cadmium induces DNA synthesis and proliferation and affects signal transduction and mobilization in macrophages. At micromolar concentrations, cadmium significantly increased cell division as judged by thymidine uptake and cell counts. Activating this pathway will increase the availability of the transcription factor NF(kappa)B and will activate the early genes c-fos and c-myc.
References
Cadmium Induces DNA Synthesis and Proliferation in Macrophages References
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Pubmed: 11858940
https://cgap.nci.nih.gov/Pathways/BioCarta/h_cdMacPathway
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Pubmed: 2203531
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Pubmed: 2234062
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Pubmed: 1992489
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Pubmed: 14702039
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