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Pathway Description
EPO Signaling Pathway
Homo sapiens
Category:
Protein Pathway
Sub-Categories:
Cytokine Signaling
Kinase Signaling
Gene Regulatory
Cellular Response
Created: 2018-08-01
Last Updated: 2019-08-16
The hormone erythropoietin, is a 166 amino acid protein with an apparent molecular weight in its native form of 39,000 Da. The molecule is heavily glycosylated since its mass derived from its amino acid content is 18,398. The selective interaction of a hormone with its target cells is usually mediated by cell membrane receptors specific for the particular hormone. Erythropoietin-responsive cells have a trypsin-sensitive receptor for the hormone which requires protein synthesis for its maintenance. Erythropoietin-responsive cells can interact with other hematopoietic growth factors, and such interactions may lead to competition for pathway-specific differentiation, particularly under conditions of high cell density. The amino-terminal region of the hormone is not involved in receptor binding.
References
EPO Signaling Pathway References
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Pubmed: 25887776
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Pubmed: 27164096
Wu P, Zhang N, Wang X, Zhang C, Li T, Ning X, Gong K: The erythropoietin/erythropoietin receptor signaling pathway promotes growth and invasion abilities in human renal carcinoma cells. PLoS One. 2012;7(9):e45122. doi: 10.1371/journal.pone.0045122. Epub 2012 Sep 18.
Pubmed: 23028796
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Pubmed: 15534001
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Pubmed: 7719937
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Pubmed: 14702039
Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A: Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. Genome Res. 1998 Oct;8(10):1060-73. doi: 10.1101/gr.8.10.1060.
Pubmed: 9799793
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Pubmed: 28283061
Jacobs K, Shoemaker C, Rudersdorf R, Neill SD, Kaufman RJ, Mufson A, Seehra J, Jones SS, Hewick R, Fritsch EF, et al.: Isolation and characterization of genomic and cDNA clones of human erythropoietin. Nature. 1985 Feb 28-Mar 6;313(6005):806-10. doi: 10.1038/313806a0.
Pubmed: 3838366
Friedman AD, Nimbalkar D, Quelle FW: Erythropoietin receptors associate with a ubiquitin ligase, p33RUL, and require its activity for erythropoietin-induced proliferation. J Biol Chem. 2003 Jul 18;278(29):26851-61. doi: 10.1074/jbc.M210039200. Epub 2003 May 13.
Pubmed: 12746455
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Pubmed: 2163695
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Pubmed: 2163696
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Pubmed: 2167438
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Pubmed: 11780052
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Pubmed: 15489334
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Pubmed: 9326218
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Pubmed: 15805263
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Pubmed: 1732748
Shen SH, Bastien L, Posner BI, Chretien P: A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases. Nature. 1991 Aug 22;352(6337):736-9. doi: 10.1038/352736a0.
Pubmed: 1652101
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