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Pathway Description
Aspartate Metabolism
Bos taurus
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2018-08-10
Last Updated: 2019-08-30
Aspartate is synthesized by transamination of oxaloacetate by aspartate aminotransferase or amino acid oxidase. Aspartyl-tRNA synthetase can then couple aspartate to aspartyl tRNA for protein synthesis. The aspartate content in human proteins is about 7%. Asparagine synthase can convert aspartate to the polar amino acid asparagine. Aspartate is also a precursor for cellular signaling compounds such as, N-acetyl-aspartate, beta-alanine, adenylsuccinate, arginino-succinate and N-carbamoylaspartate. Aspartate is also a metabolite in the urea cycle and involved in gluconeogenesis. Additionally, aspartate carries the reducing equivalents in the mitochondrial malate-aspartate shuttle, which utilizes the ready interconversion of aspartate and oxaloacetate. The conjugate base of L-aspartic acid, aspartate, also acts as an excitatory neurotransmitter in the brain which activates NMDA receptors.
References
Aspartate Metabolism References
Simonic T, Duga S, Negri A, Tedeschi G, Malcovati M, Tenchini ML, Ronchi S: cDNA cloning and expression of the flavoprotein D-aspartate oxidase from bovine kidney cortex. Biochem J. 1997 Mar 15;322 ( Pt 3):729-35. doi: 10.1042/bj3220729.
Pubmed: 9148742
Negri A, Ceciliani F, Tedeschi G, Simonic T, Ronchi S: The primary structure of the flavoprotein D-aspartate oxidase from beef kidney. J Biol Chem. 1992 Jun 15;267(17):11865-71.
Pubmed: 1601857
Kaul R, Gao GP, Balamurugan K, Matalon R: Cloning of the human aspartoacylase cDNA and a common missense mutation in Canavan disease. Nat Genet. 1993 Oct;5(2):118-23. doi: 10.1038/ng1093-118.
Pubmed: 8252036
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marcais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL: A whole-genome assembly of the domestic cow, Bos taurus. Genome Biol. 2009;10(4):R42. doi: 10.1186/gb-2009-10-4-r42. Epub 2009 Apr 24.
Pubmed: 19393038
Dennis JA, Healy PJ, Beaudet AL, O'Brien WE: Molecular definition of bovine argininosuccinate synthetase deficiency. Proc Natl Acad Sci U S A. 1989 Oct;86(20):7947-51. doi: 10.1073/pnas.86.20.7947.
Pubmed: 2813370
Jeon SG, Bahn JH, Jang JS, Jang SH, Lee BR, Lee KS, Park J, Kang TC, Won MH, Kim HB, Kwo OS, Cho SW, Choi SY: Molecular cloning and functional expression of bovine brain GABA transaminase. Mol Cells. 2001 Aug 31;12(1):91-6.
Pubmed: 11561735
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000067
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