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Pathway Description
Glutamate Metabolism
Bos taurus
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2018-08-10
Last Updated: 2019-08-16
Glutamate is one of the non-essential amino acids that is produced by the body. Glutamate is precursor for many nucleic acids and proteins in addition to its role in the central nervous system. It is an excitatory neurotransmitter and has a role in neuronal plasticity, affecting memory and learning. Glutamate plays a role in numerous metabolic pathways. Dysfunctional glutamate metabolism may cause disorders such as: gyrate atrophy, hyperammonemia, γ-hydoxybutyric aciduria, hemolytic anemia, and 5-oxoprolinuria.
References
Glutamate Metabolism References
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marcais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL: A whole-genome assembly of the domestic cow, Bos taurus. Genome Biol. 2009;10(4):R42. doi: 10.1186/gb-2009-10-4-r42. Epub 2009 Apr 24.
Pubmed: 19393038
Kim DW, Eum WS, Jang SH, Yoon CS, Kim YH, Choi SH, Choi HS, Kim SY, Kwon HY, Kang JH, Kwon OS, Cho SW, Park J, Choi SY: Molecular gene cloning, expression, and characterization of bovine brain glutamate dehydrogenase. J Biochem Mol Biol. 2003 Nov 30;36(6):545-51.
Pubmed: 14659072
Moon K, Smith EL: Sequence of bovine liver glutamate dehydrogenase. 8. Peptides produced by specific chemical cleavages; the complete sequence of the protein. J Biol Chem. 1973 May 10;248(9):3082-8.
Pubmed: 4735572
Julliard JH, Smith EL: Partial amino acid sequence of the glutamate dehydrogenase of human liver and a revision of the sequence of the bovine enzyme. J Biol Chem. 1979 May 10;254(9):3427-38.
Pubmed: 429360
Palmisano A, Aurilia V, Ferrara L, Cubellis MV, Sannia G, Marino G: Nucleotide sequence of a cDNA coding for bovine mitochondrial aspartate aminotransferase. Int J Biochem Cell Biol. 1995 May;27(5):507-11.
Pubmed: 7641080
Harhay GP, Sonstegard TS, Keele JW, Heaton MP, Clawson ML, Snelling WM, Wiedmann RT, Van Tassell CP, Smith TP: Characterization of 954 bovine full-CDS cDNA sequences. BMC Genomics. 2005 Nov 23;6:166. doi: 10.1186/1471-2164-6-166.
Pubmed: 16305752
Capasso S, Garzillo AM, Marino G, Mazzarella L, Pucci P, Sannia G: Mitochondrial bovine aspartate aminotransferase. Preliminary sequence and crystallographic data. FEBS Lett. 1979 May 15;101(2):351-4. doi: 10.1016/0014-5793(79)81042-x.
Pubmed: 446759
Childers CP, Newkirk HL, Honeycutt DA, Ramlachan N, Muzney DM, Sodergren E, Gibbs RA, Weinstock GM, Womack JE, Skow LC: Comparative analysis of the bovine MHC class IIb sequence identifies inversion breakpoints and three unexpected genes. Anim Genet. 2006 Apr;37(2):121-9. doi: 10.1111/j.1365-2052.2005.01395.x.
Pubmed: 16573526
Watabe S, Makino Y, Ogawa K, Hiroi T, Yamamoto Y, Takahashi SY: Mitochondrial thioredoxin reductase in bovine adrenal cortex its purification, properties, nucleotide/amino acid sequences, and identification of selenocysteine. Eur J Biochem. 1999 Aug;264(1):74-84. doi: 10.1046/j.1432-1327.1999.00578.x.
Pubmed: 10447675
Jeon SG, Bahn JH, Jang JS, Jang SH, Lee BR, Lee KS, Park J, Kang TC, Won MH, Kim HB, Kwo OS, Cho SW, Choi SY: Molecular cloning and functional expression of bovine brain GABA transaminase. Mol Cells. 2001 Aug 31;12(1):91-6.
Pubmed: 11561735
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000072
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