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Pathway Description
beta-Alanine Metabolism
Bos taurus
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2018-08-10
Last Updated: 2019-08-30
Beta-alanine, 3-aminopropanoic acid, is a non-essential amino acid. Beta-Alanine is formed by the proteolytic degradation of beta-alanine containing dipeptides: carnosine, anserine, balenine, and pantothenic acid (vitamin B5). These dipeptides are consumed from protein-rich foods such as chicken, beef, pork, and fish. Beta-Alanine can also be formed in the liver from the breakdown of pyrimidine nucleotides into uracil and dihydrouracil and then metabolized into beta-alanine and beta-aminoisobutyrate. Beta-Alanine can also be formed via the action of aldehyde dehydrogenase on beta-aminoproionaldehyde which is generated from various aliphatic polyamines. Under normal conditions, beta-alanine is metabolized to aspartic acid through the action of glutamate decarboxylase. It addition, it can be converted to malonate semialdehyde and thereby participate in propanoate metabolism. Beta-Alanine is not a proteogenic amino acid. This amino acid is a common athletic supplementation due to its belief to improve performance by increased muscle carnosine levels.
References
beta-Alanine Metabolism References
Arimura N, Inagaki N, Chihara K, Menager C, Nakamura N, Amano M, Iwamatsu A, Goshima Y, Kaibuchi K: Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse. J Biol Chem. 2000 Aug 4;275(31):23973-80. doi: 10.1074/jbc.M001032200.
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Rahajeng J, Giridharan SS, Naslavsky N, Caplan S: Collapsin response mediator protein-2 (Crmp2) regulates trafficking by linking endocytic regulatory proteins to dynein motors. J Biol Chem. 2010 Oct 15;285(42):31918-22. doi: 10.1074/jbc.C110.166066. Epub 2010 Aug 27.
Pubmed: 20801876
Albin N, Johnson MR, Diasio RB: cDNA cloning of bovine liver dihydropyrimidine dehydrogenase. DNA Seq. 1996;6(4):243-50.
Pubmed: 8912928
Porter DJ, Chestnut WG, Taylor LC, Merrill BM, Spector T: Inactivation of dihydropyrimidine dehydrogenase by 5-iodouracil. J Biol Chem. 1991 Oct 25;266(30):19988-94.
Pubmed: 1939061
Jeon SG, Bahn JH, Jang JS, Jang SH, Lee BR, Lee KS, Park J, Kang TC, Won MH, Kim HB, Kwo OS, Cho SW, Choi SY: Molecular cloning and functional expression of bovine brain GABA transaminase. Mol Cells. 2001 Aug 31;12(1):91-6.
Pubmed: 11561735
Deichaite I, Berthiaume L, Peseckis SM, Patton WF, Resh MD: Novel use of an iodo-myristyl-CoA analog identifies a semialdehyde dehydrogenase in bovine liver. J Biol Chem. 1993 Jun 25;268(18):13738-47.
Pubmed: 8514806
Guan KL, Weiner H: Sequence of the precursor of bovine liver mitochondrial aldehyde dehydrogenase as determined from its cDNA, its gene, and its functionality. Arch Biochem Biophys. 1990 Mar;277(2):351-60. doi: 10.1016/0003-9861(90)90590-u.
Pubmed: 1689984
Farres J, Guan KL, Weiner H: Primary structures of rat and bovine liver mitochondrial aldehyde dehydrogenases deduced from cDNA sequences. Eur J Biochem. 1989 Mar 1;180(1):67-74. doi: 10.1111/j.1432-1033.1989.tb14616.x.
Pubmed: 2540003
Lee JE, Cho YD: Purification and characterization of bovine brain gamma-aminobutyraldehyde dehydrogenase. Biochem Biophys Res Commun. 1992 Nov 30;189(1):450-4.
Pubmed: 1449496
Harhay GP, Sonstegard TS, Keele JW, Heaton MP, Clawson ML, Snelling WM, Wiedmann RT, Van Tassell CP, Smith TP: Characterization of 954 bovine full-CDS cDNA sequences. BMC Genomics. 2005 Nov 23;6:166. doi: 10.1186/1471-2164-6-166.
Pubmed: 16305752
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000007
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