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Alpha-
aminoadipic
semialdehyde
dehydrogenase
Betaine--
homocysteine S-
methyltransferase
1
Methionine
synthase
S-
adenosylmethionine
synthase
isoform type-1
Methionine
adenosyltransferase
2 subunit beta
Adenosylhomocysteinase
Choline
dehydrogenase
Phosphatidylethanolamine
N-
methyltransferase
Tetrahydrofolic acid
5-Methyltetrahydrofolic acid
βine
βine
Choline
Choline
βine aldehyde
NAD
H
2
O
NADH
Homocysteine
Dimethylglycine
L-Methionine
ATP
H
2
O
S-Adenosylmethionine
P
i
PP
i
S-Adenosylhomocysteine
H
2
O
Adenosine
Phosphatidyl-ethanolamide
Phosphatidyl-N-
methylethanolamine
Zinc (II) ion
Zinc (II) ion
Magnesium
Potassium
NAD
FAD
Acceptor
Reduced
acceptor
One Carbon Pool
by Folate
Extracellular Space
Intracellular Space
Liver
Kidney
ALDH7A1
BHMT
MTR
MAT1A
MAT2B
AHCY
CHDH
PEMT
Tetrahydrofolic
acid
5-
Methyltetrahydrofolic
acid
βine
βine
Choline
Choline
βine aldehyde
NAD
Water
NADH
Homocysteine
Dimethylglycine
L-Methionine
Adenosine
triphosphate
Water
S-
Adenosylmethionine
Phosphate
Pyrophosphate
S-
Adenosylhomocysteine
Water
Adenosine
Phosphatidyl-
ethanolamide
Phosphatidyl-
N-
methylethanolamine
Acceptor
Reduced
acceptor
One Carbon Pool
by Folate