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Cytochrome P450
2U1
Cytochrome P450
2U1
Cytochrome P450
2E1
Unknown
Cytochrome P450
2U1
Cytochrome P450
3A28
Cytochrome P450
2E1
Cytochrome P450
2E1
Cytochrome P450
2E1
Cytochrome P450
2U1
Cytochrome P450
2U1
Xanthine
dehydrogenase/oxidase
Xanthine
dehydrogenase/oxidase
Cytochrome P450
2U1
Cytochrome P450
3A28
Cytochrome P450
2E1
Cytochrome P450
2E1
Cytochrome P450
2E1
Cytochrome P450
2U1
Cytochrome P450
2E1
Xanthine
dehydrogenase/oxidase
5-Acetylamino-6-formylamino-
3-methyluracil
5-Acetylamino-6-amino-3-
methyluracil
Caffeine
NADH
O
2
Paraxanthine
NAD
H
2
O
Formaldehyde
NADH
O
2
Theobromine
NAD
H
2
O
Formaldehyde
Acetyl-CoA
CoA
NADH
O
2
Theophylline
NAD
H
2
O
Formaldehyde
NADH
O
2
7-Methylxanthine
NAD
H
2
O
Formaldehyde
NADH
O
2
1-Methylxanthine
NAD
H
2
O
Formaldehyde
H
2
O
O
2
1-Methyluric acid
H
2
O
2
O
2
H
2
O
7-Methyluric acid
H
2
O
2
O
2
H
2
O
1,3,7-Trimethyluric acid
H
2
O
2
O
2
H
2
O
1,7-Dimethyluric acid
H
2
O
2
H
2
O
O
2
3,7-Dimethyluric acid
H
2
O
2
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
FAD
2Fe-2S
Molybdopterin
FAD
2Fe-2S
Molybdopterin
Heme
Heme
Heme
Heme
Heme
Heme
Heme
FAD
2Fe-2S
Molybdopterin
Endoplasmic Reticulum
ER Membrane
ER Lumen
Lysosome
Lysosomal Lumen
Lysosomal Membrane
Liver
Endoplasmic Reticulum
Lysosome
CYP2U1
CYP2U1
CYP2E1
Unknown
CYP2U1
CYP3A28
CYP2E1
CYP2E1
CYP2E1
CYP2U1
CYP2U1
XDH
XDH
CYP2U1
CYP3A28
CYP2E1
CYP2E1
CYP2E1
CYP2U1
CYP2E1
XDH
5- Acetylamino-
6- formylamino-
3- methyluracil
5- Acetylamino-
6-amino-3-
methyluracil
Caffeine
NADH
Oxygen
Paraxanthine
NAD
Water
Formaldehyde
NADH
Oxygen
Theobromine
NAD
Water
Formaldehyde
Acetyl-CoA
Coenzyme A
NADH
Oxygen
Theophylline
NAD