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Proton-coupled folate transporter Dihydrofolate reductase Dihydrofolate reductase Monofunctional C1- tetrahydrofolate synthase, mitochondrial Retinal dehydrogenase 1 Formimidoyltransferase cyclodeaminase Monofunctional C1- tetrahydrofolate synthase, mitochondrial 5- formyltetrahydrofolate cyclo-ligase Monofunctional C1- tetrahydrofolate synthase, mitochondrial Methylenetetrahydrofolate reductase Formimidoyltransferase cyclodeaminase Folylpolyglutamate synthase, mitochondrial Folylpolyglutamate synthase, mitochondrial Gamma-glutamyl hydrolase Monofunctional C1- tetrahydrofolate synthase, mitochondrial Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial Methionyl-tRNA formyltransferase, mitochondrial Tetrahydrofolic acid Dihydrofolic acid L-Glutamic acid 5-Formiminotetrahydrofolic acid 5,10-Methylene-THF 5-Methyltetrahydrofolic acid 10-Formyltetrahydrofolate Tetrahydrofolic acid 5,10-Methylene-THF Folic acid Folic acid NADP NADPH NADP NADPH ATP Formic acid ADP Pi NADP H2O CO2 NADPH N5-Formyl-THF N-Formyl-L- glutamic acid H+ 5,10-Methenyltetrahydrofolic acid H2O ATP ADP Pi NADPH NADP NADH NAD NH3 L-Glutamic acid ATP Tetrahydrofolyl-[Glu](2) ADP Pi ATP L-Glutamic acid Tetrahydrofolyl-[Glu](n) ADP Pi H2O L-Glutamic acid ATP Formic acid ADP 10-Formyltetrahydrofolate Pi H+ 5,10-Methenyltetrahydrofolic acid H2O NADH NAD Pyridoxal 5'-phosphate Magnesium FAD Pyridoxal 5'-phosphate Calcium Calcium Magnesium Magnesium L- Methionyl- tRNA(Met) N- formylmethionyl- tRNA(fMet) Histidine Metabolism Purine Metabolism Methionine Metabolism Glycine and Serine Metabolism Pyrimidine Metabolism Glutamate Metabolism Histidine Metabolism Glycine and Serine Metabolism Pyrimidine Metabolism Methionine Metabolism Purine Metabolism Glycine and Serine Metabolism Glycine and Serine Metabolism Mitochondria Lysosome Extracellular Space Intracellular Space Mitochondrial matrix
Mitochondria SLC46A1 DHFR DHFR MTHFD1L ALDH1A1 FTCD MTHFD1L MTHFS MTHFD1L MTHFR FTCD FPGS FPGS GGH MTHFD1L MTHFD2 MTHFD2 MTFMT Tetrahydrofolic acid Dihydrofolic acid L-Glutamic acid 5- Formiminotetrahydrofolic acid 5,10- Methylene-THF 5- Methyltetrahydrofolic acid 10- Formyltetrahydrofolate Tetrahydrofolic acid 5,10- Methylene-THF Folic acid Folic acid NADP NADPH NADP NADPH Adenosine triphosphate Formic acid Adenosine diphosphate Phosphate NADP Water Carbon dioxide NADPH N5-Formyl-THF N-Formyl-L- glutamic acid Hydrogen Ion 5,10- Methenyltetrahydrofolic acid Water Adenosine triphosphate Adenosine diphosphate Phosphate NADPH NADP NADH NAD Ammonia L-Glutamic acid Adenosine triphosphate Tetrahydrofolyl- [Glu](2) Adenosine diphosphate Phosphate Adenosine triphosphate L-Glutamic acid Tetrahydrofolyl- [Glu](n) Adenosine diphosphate Phosphate Water L-Glutamic acid Adenosine triphosphate Formic acid Adenosine diphosphate 10- Formyltetrahydrofolate Phosphate Hydrogen Ion 5,10- Methenyltetrahydrofolic acid Water NADH NAD L- Methionyl- tRNA(Met) N- formylmethionyl- tRNA(fMet) Histidine Metabolism Purine Metabolism Methionine Metabolism Glycine and Serine Metabolism Pyrimidine Metabolism Glutamate Metabolism Histidine Metabolism Glycine and Serine Metabolism Pyrimidine Metabolism Methionine Metabolism Purine Metabolism Glycine and Serine Metabolism Glycine and Serine Metabolism