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Pathway Description
Fructose and Mannose Degradation
Bos taurus
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2018-08-10
Last Updated: 2019-08-16
Fructose and mannose are monosaccharides that can be found in many foods. Fructose can join with glucose to form sucrose. Mannose can be converted to glucose. Both may be used as food sweeteners. Fructose is well absorbed, especially in the presence of glucose. Fructose causes less of an insulin response compared to glucose and thus may be a preferred sugar for diabetics. In contrast to fructose, humans do not metabolize mannose well with the majority of it being excreted unchanged. Mannose in the urine can be beneficial in treating urinary tract infections caused be E. coli. However, mannose can be detrimental to humans by causing diabetic complications.
References
Fructose and Mannose Degradation References
Schade SZ, Early SL, Williams TR, Kezdy FJ, Heinrikson RL, Grimshaw CE, Doughty CC: Sequence analysis of bovine lens aldose reductase. J Biol Chem. 1990 Mar 5;265(7):3628-35.
Pubmed: 2105951
Harhay GP, Sonstegard TS, Keele JW, Heaton MP, Clawson ML, Snelling WM, Wiedmann RT, Van Tassell CP, Smith TP: Characterization of 954 bovine full-CDS cDNA sequences. BMC Genomics. 2005 Nov 23;6:166. doi: 10.1186/1471-2164-6-166.
Pubmed: 16305752
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marcais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL: A whole-genome assembly of the domestic cow, Bos taurus. Genome Biol. 2009;10(4):R42. doi: 10.1186/gb-2009-10-4-r42. Epub 2009 Apr 24.
Pubmed: 19393038
Marini I, Bucchioni L, Borella P, Del Corso A, Mura U: Sorbitol dehydrogenase from bovine lens: purification and properties. Arch Biochem Biophys. 1997 Apr 15;340(2):383-91. doi: 10.1006/abbi.1997.9882.
Pubmed: 9143345
Griffin LD, MacGregor GR, Muzny DM, Harter J, Cook RG, McCabe ER: Synthesis and characterization of a bovine hexokinase 1 cDNA probe by mixed oligonucleotide primed amplification of cDNA using high complexity primer mixtures. Biochem Med Metab Biol. 1989 Apr;41(2):125-31.
Pubmed: 2719857
Griffin LD, Gelb BD, Wheeler DA, Davison D, Adams V, McCabe ER: Mammalian hexokinase 1: evolutionary conservation and structure to function analysis. Genomics. 1991 Dec;11(4):1014-24.
Pubmed: 1783373
Lange AJ, el-Maghrabi MR, Pilkis SJ: Isolation of bovine liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase cDNA: bovine liver and heart forms of the enzyme are separate gene products. Arch Biochem Biophys. 1991 Oct;290(1):258-63. doi: 10.1016/0003-9861(91)90617-r.
Pubmed: 1654864
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000064
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