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Pathway Description
Nucleotide Sugars Metabolism
Bos taurus
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2018-08-10
Last Updated: 2019-08-16
Nucleotide sugars are defined as any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. There are nine sugar nucleotides and they can be classified depending on the type of the nucleoside forming them: UDP-Glc, UDP-Gal, UDP-GlcNAc, UDP-GlcUA, UDP- Xyl, GDP-Man, GDP-Fuc and CMP-NeuNAc.
Turning back now to the pathway in question, namely the nucleotide sugar metabolism pathway, it should be noted that the nucleotide sugars play an important role. Indeed, they are donors of certain important residues of sugar which are vital to glycosylation and by extension tot the production of polysaccharides. This process produces the substrates for glycosyltransferases. These sugars have several additional roles. For example, nucleotide sugars serve a vital purpose as the intermediates in interconversions of nucleotide sugars that result in the creation and activation of certain sugars necessary in the glycosylation reaction in certain organisms.
Moreover, the process of glycosylation is attributed mostly (though not entirely) to the endoplasmic reticulum/golgi apparatus. Logically then, due to the important role of nucleotide sugars in glycosylation, a plethora of transporters exist which displace the sugars from their point of production, the cytoplasm, to where they are needed. In the case, the endoplasmic reticulum and golgi apparatus.
References
Nucleotide Sugars Metabolism References
Griffin LD, MacGregor GR, Muzny DM, Harter J, Cook RG, McCabe ER: Synthesis and characterization of a bovine hexokinase 1 cDNA probe by mixed oligonucleotide primed amplification of cDNA using high complexity primer mixtures. Biochem Med Metab Biol. 1989 Apr;41(2):125-31.
Pubmed: 2719857
Griffin LD, Gelb BD, Wheeler DA, Davison D, Adams V, McCabe ER: Mammalian hexokinase 1: evolutionary conservation and structure to function analysis. Genomics. 1991 Dec;11(4):1014-24.
Pubmed: 1783373
Konishi Y, Tanizawa K, Muroya S, Fukui T: Molecular cloning, nucleotide sequencing, and affinity labeling of bovine liver UDP-glucose pyrophosphorylase. J Biochem. 1993 Jul;114(1):61-8. doi: 10.1093/oxfordjournals.jbchem.a124141.
Pubmed: 8407878
Lind T, Falk E, Hjertson E, Kusche-Gullberg M, Lidholt K: cDNA cloning and expression of UDP-glucose dehydrogenase from bovine kidney. Glycobiology. 1999 Jun;9(6):595-600. doi: 10.1093/glycob/9.6.595.
Pubmed: 10336992
Hempel J, Perozich J, Romovacek H, Hinich A, Kuo I, Feingold DS: UDP-glucose dehydrogenase from bovine liver: primary structure and relationship to other dehydrogenases. Protein Sci. 1994 Jul;3(7):1074-80. doi: 10.1002/pro.5560030710.
Pubmed: 7920253
Franzen B, Carrubba C, Feingold DS, Ashcom J, Franzen JS: Amino acid sequence of the tryptic peptide containing the catalytic-site thiol group of bovine liver uridine diphosphate glucose dehydrogenase. Biochem J. 1981 Dec 1;199(3):599-602. doi: 10.1042/bj1990599.
Pubmed: 6896145
Smith TP, Grosse WM, Freking BA, Roberts AJ, Stone RT, Casas E, Wray JE, White J, Cho J, Fahrenkrug SC, Bennett GL, Heaton MP, Laegreid WW, Rohrer GA, Chitko-McKown CG, Pertea G, Holt I, Karamycheva S, Liang F, Quackenbush J, Keele JW: Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Genome Res. 2001 Apr;11(4):626-30. doi: 10.1101/gr.170101.
Pubmed: 11282978
Harhay GP, Sonstegard TS, Keele JW, Heaton MP, Clawson ML, Snelling WM, Wiedmann RT, Van Tassell CP, Smith TP: Characterization of 954 bovine full-CDS cDNA sequences. BMC Genomics. 2005 Nov 23;6:166. doi: 10.1186/1471-2164-6-166.
Pubmed: 16305752
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marcais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL: A whole-genome assembly of the domestic cow, Bos taurus. Genome Biol. 2009;10(4):R42. doi: 10.1186/gb-2009-10-4-r42. Epub 2009 Apr 24.
Pubmed: 19393038
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000010
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