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Cytosolic
non-specific
dipeptidase
Uncharacterized
protein
Protein
arginine N-
methyltransferase
6
Histidine
decarboxylase
Histamine N-
methyltransferase
Amine oxidase
[flavin-
containing] A
Aldehyde
dehydrogenase
family 3 member
B1
Aldehyde
dehydrogenase,
mitochondrial
Histidine
ammonia-lyase
Urocanate
hydratase 1
Probable
imidazolonepropionase
Formimidoyltransferase
cyclodeaminase
Membrane
primary amine
oxidase
Unknown
Uncharacterized
protein
Cytosolic
non-specific
dipeptidase
Probable
histidine--tRNA
ligase,
mitochondrial
Histidine--tRNA
ligase,
cytoplasmic
L-Glutamic acid
Carnosine
H
2
O
β-Alanine
L-Histidine
ATP
β-Alanine
ADP
P
i
S-Adenosylmethionine
3-
Methylhistidine
S-Adenosylhomocysteine
Histamine
CO
2
S-Adenosylmethionine
S-Adenosylhomocysteine
1-Methylhistamine
H
2
O
O
2
Methylimidazole acetaldehyde
NH
3
H
2
O
2
NADP
H
2
O
Methylimidazoleacetic acid
NADPH
H
+
Imidazole-4-acetaldehyde
NAD
H
2
O
Imidazoleacetic acid
NADH
H
+
NH
3
Urocanic acid
4-Imidazolone-5-propionic acid
H
2
O
H
2
O
Formiminoglutamic acid
Tetrahydrofolic acid
5-Formiminotetrahydrofolic
acid
H
2
O
O
2
NH
3
H
2
O
2
S-
Adenosylmethionine
S-
Adenosylhomocysteine
Anserine
ATP
1-Methylhistidine
β-Alanine
ADP
P
i
H
2
O
β-Alanine
ATP
AMP
PP
i
ATP
AMP
PP
i
Zinc (II) ion
Manganese
Pyridoxal
5'-phosphate
FAD
NAD
Zinc (II) ion
Pyridoxal
5'-phosphate
Copper
Calcium
Topaquinone
tRNA(His)
L- Histidyl-
tRNA(His)
tRNA(His)
Glutamate
Metabolism
Manganese
Manganese
Intracellular Space
Extracellular Space