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Cytochrome P450
3A28
Leukotriene A-4
hydrolase
Leukotriene C4
synthase
Glutathione
hydrolase 7
Glutathione
peroxidase 1
Prostacyclin
synthase
Prostaglandin-
H2 D-isomerase
Dihydrodiol
dehydrogenase 3
Thromboxane-A
synthase
Prostaglandin E
synthase
Prostamide/prostaglandin
F synthase
Carbonyl
reductase
[NADPH] 1
Arachidonate
15-lipoxygenase
Cytochrome P450
2E1
Cytochrome P450
2E1
Cytochrome P450
2E1
Cytochrome P450
2E1
Cytochrome P450
2E1
Cytochrome P450
2E1
Epoxide
hydratase 2
Cytochrome P450
2E1
Epoxide
hydratase 2
Arachidonate
15-lipoxygenase
Arachidonate
15-lipoxygenase
Glutathione
peroxidase 1
Prostaglandin
G/H synthase 1
Prostaglandin
G/H synthase 2
Prostaglandin
G/H synthase 1
Prostaglandin
G/H synthase 2
Cytochrome P450
2E1
Epoxide
hydratase 2
Cytochrome P450
2E1
Epoxide
hydratase 2
Arachidonate
15-lipoxygenase
Cytochrome P450
2E1
Arachidonate
15-lipoxygenase
Cytochrome P450
2D14
Cytochrome P450
2U1
Cytochrome P450
3A28
Cytochrome P450
2U1
Arachidonate
15-lipoxygenase
Cytosolic
phospholipase
A2
Cytochrome P450
3A28
Cytochrome P450
3A28
20-Hydroxy-leukotriene B4
20-Carboxy-leukotriene B4
Leukotriene B4
NADPH
O
2
NADP
H
2
O
Leukotriene A4
H
2
O
12-Keto-leukotriene B4
Glutathione
Leukotriene C4
H
2
O
Leukotriene D4
L-Glutamic acid
5,6-Epoxytetraene
15(S)-HPETE
Glutathione
15(S)-HETE
Oxidized glutathione
H
2
O
δ-12-Prostaglandin J2
15-Deoxy-d-12,14-PGJ2
6-Keto-prostaglandin F1a
6-Ketoprostaglandin E1
5-HETE
5-KETE
Prostaglandin J2
Prostaglandin I2
Prostaglandin D2
Prostaglandin H2
NADPH
11-Epi-PGF2a
NADP
Thromboxane A2
Prostaglandin E2
Prostaglandin F2a
NADPH
NADP
Prostaglandin A2
Prostaglandin-c2
Thromboxane B2
Prostaglandin B2
11-Dehydro-thromboxane B2
Arachidonic acid
O
2
O
2
11H-14,15-EETA
H
2
O
O
2
11,14,15-THETA
H
2
O
O
2
15H-11,12-EETA
H
2
O
O
2
11,12,15-THETA
H
2
O
O
2
16(R)-HETE
H
2
O
O
2
14,15-Epoxy-5,8,11-
eicosatrienoic acid
H
2
O
H
2
O
14,15-DiHETrE
O
2
11,12-Epoxyeicosatrienoic acid
H
2
O
H
2
O
11,12-DiHETrE
5-HPETE