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Cytochrome P450 3A28 Leukotriene A-4 hydrolase Leukotriene C4 synthase Glutathione hydrolase 7 Glutathione peroxidase 1 Prostacyclin synthase Prostaglandin- H2 D-isomerase Dihydrodiol dehydrogenase 3 Thromboxane-A synthase Prostaglandin E synthase Prostamide/prostaglandin F synthase Carbonyl reductase [NADPH] 1 Arachidonate 15-lipoxygenase Cytochrome P450 2E1 Cytochrome P450 2E1 Cytochrome P450 2E1 Cytochrome P450 2E1 Cytochrome P450 2E1 Cytochrome P450 2E1 Epoxide hydratase 2 Cytochrome P450 2E1 Epoxide hydratase 2 Arachidonate 15-lipoxygenase Arachidonate 15-lipoxygenase Glutathione peroxidase 1 Prostaglandin G/H synthase 1 Prostaglandin G/H synthase 2 Prostaglandin G/H synthase 1 Prostaglandin G/H synthase 2 Cytochrome P450 2E1 Epoxide hydratase 2 Cytochrome P450 2E1 Epoxide hydratase 2 Arachidonate 15-lipoxygenase Cytochrome P450 2E1 Arachidonate 15-lipoxygenase Cytochrome P450 2D14 Cytochrome P450 2U1 Cytochrome P450 3A28 Cytochrome P450 2U1 Arachidonate 15-lipoxygenase Cytosolic phospholipase A2 Cytochrome P450 3A28 Cytochrome P450 3A28 20-Hydroxy-leukotriene B4 20-Carboxy-leukotriene B4 Leukotriene B4 NADPH O2 NADP H2O Leukotriene A4 H2O 12-Keto-leukotriene B4 Glutathione Leukotriene C4 H2O Leukotriene D4 L-Glutamic acid 5,6-Epoxytetraene 15(S)-HPETE Glutathione 15(S)-HETE Oxidized glutathione H2O δ-12-Prostaglandin J2 15-Deoxy-d-12,14-PGJ2 6-Keto-prostaglandin F1a 6-Ketoprostaglandin E1 5-HETE 5-KETE Prostaglandin J2 Prostaglandin I2 Prostaglandin D2 Prostaglandin H2 NADPH 11-Epi-PGF2a NADP Thromboxane A2 Prostaglandin E2 Prostaglandin F2a NADPH NADP Prostaglandin A2 Prostaglandin-c2 Thromboxane B2 Prostaglandin B2 11-Dehydro-thromboxane B2 Arachidonic acid O2 O2 11H-14,15-EETA H2O O2 11,14,15-THETA H2O O2 15H-11,12-EETA H2O O2 11,12,15-THETA H2O O2 16(R)-HETE H2O O2 14,15-Epoxy-5,8,11- eicosatrienoic acid H2O H2O 14,15-DiHETrE O2 11,12-Epoxyeicosatrienoic acid H2O H2O 11,12-DiHETrE 5-HPETE O2 H2O O2 H2O Glutathione Oxidized glutathione H2O Prostaglandin G2 H2O O2 O2 8,9-Epoxyeicosatrienoic acid H2O H2O 8,9-DiHETrE O2 5,6-Epoxy-8,11,14- eicosatrienoic acid H2O H2O 5,6-DHET O2 8(S)-HPETE O2 19(S)-HETE H2O O2 12(R)-HPETE 8-HETE Arachidonic acid 8-Isoprostane O2 H2O O2 H2O O2 20-Hydroxyeicosatetraenoic acid H2O O2 H2O O2 12(S)-HPETE 12(R)-HETE 12-KETE 12(S)-HETE PC(14:0/20:4(5Z,8Z,11Z,14Z)) H2O LysoPC(14:0/0:0) NADPH O2 NADP H2O 2,3-Dinor-8iso prostaglandin F1α 2,3-Dinor-8iso prostaglandin F2α Heme Zinc (II) ion Heme Heme Glutathione Fe3+ Heme Heme Heme Heme Heme Heme Magnesium Heme Magnesium Fe3+ Calcium Fe3+ Calcium Heme Heme Heme Heme Heme Magnesium Heme Magnesium Fe3+ Heme Fe3+ Heme Heme Heme Heme Fe3+ Calcium Heme Heme Cytosol Lumen Lumen Cytosol Lumen Cytosol Lumen Cytosol Lumen Smooth Endoplasmic Reticulum Extracellular Space Intracellular Space
Endoplasmic Reticulum CYP3A28 LTA4H LTC4S GGT7 GPX1 PTGIS PTGDS Unknown TBXAS1 PTGES FAM213B CBR1 ALOX15 CYP2E1 CYP2E1 CYP2E1 CYP2E1 CYP2E1 CYP2E1 EPHX2 CYP2E1 EPHX2 ALOX15 ALOX15 GPX1 PTGS1 PTGS2 PTGS1 PTGS2 CYP2E1 EPHX2 CYP2E1 EPHX2 ALOX15 CYP2E1 ALOX15 CYP2D14 CYP2U1 CYP3A28 CYP2U1 ALOX15 PLA2G4A CYP3A28 CYP3A28 20-Hydroxy- leukotriene B4 20-Carboxy- leukotriene B4 Leukotriene B4 NADPH Oxygen NADP Water Leukotriene A4 Water 12-Keto- leukotriene B4 Glutathione Leukotriene C4 Water Leukotriene D4 L-Glutamic acid 5,6- Epoxytetraene 15(S)-HPETE Glutathione 15(S)-HETE Oxidized glutathione Water δ-12- Prostaglandin J2 15-Deoxy-d- 12,14-PGJ2 6-Keto- prostaglandin F1a 6- Ketoprostaglandin E1 5-HETE 5-KETE Prostaglandin J2 Prostaglandin I2 Prostaglandin D2 Prostaglandin H2 NADPH 11-Epi-PGF2a NADP Thromboxane A2 Prostaglandin E2 Prostaglandin F2a NADPH NADP Prostaglandin A2 Prostaglandin- c2 Thromboxane B2 Prostaglandin B2 11-Dehydro- thromboxane B2 Arachidonic acid Oxygen Oxygen 11H-14,15-EETA Water Oxygen 11,14,15-THETA Water Oxygen 15H-11,12-EETA Water Oxygen 11,12,15-THETA Water Oxygen 16(R)-HETE Water Oxygen 14,15-Epoxy- 5,8,11- eicosatrienoic acid Water Water 14,15-DiHETrE Oxygen 11,12- Epoxyeicosatrienoic acid Water Water 11,12-DiHETrE 5-HPETE Oxygen Water Oxygen Water Glutathione Oxidized glutathione Water Prostaglandin G2 Water Oxygen Oxygen 8,9- Epoxyeicosatrienoic acid Water Water 8,9-DiHETrE Oxygen 5,6-Epoxy- 8,11,14- eicosatrienoic acid Water Water 5,6-DHET Oxygen 8(S)-HPETE Oxygen 19(S)-HETE Water Oxygen 12(R)-HPETE 8-HETE Arachidonic acid 8-Isoprostane Oxygen Water Oxygen Water Oxygen 20- Hydroxyeicosatetraenoic acid Water Oxygen Water Oxygen 12(S)-HPETE 12(R)-HETE 12-KETE 12(S)-HETE PC(14:0/20:4(5Z,8Z,11Z,14Z)) Water LysoPC(14:0/0:0) NADPH Oxygen NADP Water 2,3-Dinor-8iso prostaglandin F1α 2,3-Dinor-8iso prostaglandin F2α
CYP3A28 LTA4H LTC4S GGT7 GPX1 PTGIS PTGDS TBXAS1 PTGES FAM213B CBR1 ALOX15 CYP2E1 CYP2E1 CYP2E1 CYP2E1 CYP2E1 CYP2E1 EPHX2 CYP2E1 EPHX2 ALOX15 ALOX15 GPX1 PTGS1 PTGS2 PTGS1 PTGS2 CYP2E1 EPHX2 CYP2E1 EPHX2 ALOX15 CYP2E1 ALOX15 CYP2D14 CYP2U1 CYP3A28 CYP2U1 ALOX15 PLA2G4A CYP3A28 CYP3A28 HLeukB4 20CLuB4 LTB4 NADPH O2 NADP H2O LTA4 H2O KtLeuB4 GSH LTC4 H2O LTD4 Glu 56Ept 15SHPET GSH 15SHETE GSSG H2O 12-PGln 15DPGJ2 6KPgF1a 6-Kpge1 5-HETE 5-KETE PGJ2 PrstgI2 ProglD2 PGH2 NADPH EiPGF2a NADP ThrmbA2 PGE2 PGF2a NADPH NADP PGA2 ProC2 TXB2 PGB2 11DTB2 20:4 O2 O2 11H1415 H2O O2 1415THA H2O O2 111EETA H2O O2 1215THA H2O O2 16-Hete H2O O2 11E581E H2O H2O 14,15DH O2 11EpcA H2O H2O 11,12DH 5-HPETE O2 H2O O2 H2O GSH GSSG H2O PGG2 H2O O2 O2 89EEsta H2O H2O 89DHET O2 56EEsta H2O H2O 56DHET O2 8SHPETE O2 19SHETE H2O O2 12RHPET 8-HETE 20:4 8-Isop O2 H2O O2 H2O O2 20-HETE H2O O2 H2O O2 12SHPET 12RHETE 12-KETE 12SHETE PC14204 H2O LPC14:0 NADPH O2 NADP H2O DisPF1a DisPF2a Heme Zinc Heme Heme GSH Fe3+ Heme Heme Heme Heme Heme Heme Mg2+ Heme Mg2+ Fe3+ Ca2+ Fe3+ Ca2+ Heme Heme Heme Heme Heme Mg2+ Heme Mg2+ Fe3+ Heme Fe3+ Heme Heme Heme Heme Fe3+ Ca2+ Heme Heme Cytosol Lumen Lumen Cytosol Lumen Cytosol Lumen Cytosol Lumen Smooth Endoplasmic Reticulum Extracellular Space Intracellular Space
Endoplasmic Reticulum CYP3A28 LTA4H LTC4S GGT7 GPX1 PTGIS PTGDS TBXAS1 PTGES FAM213B CBR1 ALOX15 CYP2E1 CYP2E1 CYP2E1 CYP2E1 CYP2E1 CYP2E1 EPHX2 CYP2E1 EPHX2 ALOX15 ALOX15 GPX1 PTGS1 PTGS2 PTGS1 PTGS2 CYP2E1 EPHX2 CYP2E1 EPHX2 ALOX15 CYP2E1 ALOX15 CYP2D14 CYP2U1 CYP3A28 CYP2U1 ALOX15 PLA2G4A CYP3A28 CYP3A28 HLeukB4 20CLuB4 LTB4 NADPH O2 NADP H2O LTA4 H2O KtLeuB4 GSH LTC4 H2O LTD4 Glu 56Ept 15SHPET GSH 15SHETE GSSG H2O 12-PGln 15DPGJ2 6KPgF1a 6-Kpge1 5-HETE 5-KETE PGJ2 PrstgI2 ProglD2 PGH2 NADPH EiPGF2a NADP ThrmbA2 PGE2 PGF2a NADPH NADP PGA2 ProC2 TXB2 PGB2 11DTB2 20:4 O2 O2 11H1415 H2O O2 1415THA H2O O2 111EETA H2O O2 1215THA H2O O2 16-Hete H2O O2 11E581E H2O H2O 14,15DH O2 11EpcA H2O H2O 11,12DH 5-HPETE O2 H2O O2 H2O GSH GSSG H2O PGG2 H2O O2 O2 89EEsta H2O H2O 89DHET O2 56EEsta H2O H2O 56DHET O2 8SHPETE O2 19SHETE H2O O2 12RHPET 8-HETE 20:4 8-Isop O2 H2O O2 H2O O2 20-HETE H2O O2 H2O O2 12SHPET 12RHETE 12-KETE 12SHETE PC14204 H2O LPC14:0 NADPH O2 NADP H2O DisPF1a DisPF2a