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3-ketoacyl-CoA
thiolase,
mitochondrial
Mevalonate
kinase
Phosphomevalonate
kinase
Diphosphomevalonate
decarboxylase
Isopentenyl-
diphosphate
Delta-isomerase
1
Farnesyl
pyrophosphate
synthase
Geranylgeranyl
pyrophosphate
synthase
Farnesyl
pyrophosphate
synthase
Geranylgeranyl
pyrophosphate
synthase
Squalene
synthase
Squalene
epoxidase
Lanosterol
synthase
24-
dehydrocholesterol
reductase
Lanosterol
14-alpha
demethylase
Delta(14)-
sterol
reductase
24-
dehydrocholesterol
reductase
Methylsterol
monooxygenase 1
Sterol-4-
alpha-
carboxylate 3-
dehydrogenase,
decarboxylating
HSD17B7 protein
Emopamil
binding protein
(Sterol
isomerase)
24-
dehydrocholesterol
reductase
24-
dehydrocholesterol
reductase
Emopamil
binding protein
(Sterol
isomerase)
Emopamil
binding protein
(Sterol
isomerase)
Sterol-C5-
desaturase
(ERG3 delta-5-
desaturase
homolog, S.
cerevisiae)-
like
24-
dehydrocholesterol
reductase
24-
dehydrocholesterol
reductase
3-hydroxy-3-
methylglutaryl-
coenzyme A
reductase
Diacylglycerol
O-
acyltransferase
1
Gastric
triacylglycerol
lipase
Acetoacetyl-CoA
Acetyl-CoA
Cholesterol
CoA
H
2
O
3-Hydroxy-3-methylglutaryl-CoA
CoA
Mevalonic acid
ATP
Mevalonic acid-5P
ADP
ATP
ADP
(S)-5-Diphosphomevalonic acid
ATP
ADP
P
i
Isopentenyl pyrophosphate
CO
2
Dimethylallylpyrophosphate
Geranyl-PP
PP
i
Farnesyl pyrophosphate
PP
i
NADPH
Squalene
NADP
PP
i
O
2
NADPH
(S)-2,3-Epoxysqualene
H
2
O
NADP
Lanosterol
NADPH
24,25-Dihydrolanosterol
NADP
O
2
NADPH
4,4-Dimethylcholesta-
8,14,24-trienol
Formic acid
NADP
H
2
O
NADPH
4,4-Dimethyl-5a-cholesta-
8,24-dien-3-b-ol
NADP
NADPH
4,4-Dimethyl-5a-cholesta-8-
en-3b-ol
NADP
NADPH
O
2
4a-Methylzymosterol-4-
carboxylic acid
NADP
H
2
O
NADP
3-Keto-4-methylzymosterol
NADPH
CO
2
NADPH
4a-Methylzymosterol
NADP
Zymosterol intermediate 2
5a-Cholesta-7,24-dien-3b-ol
NADPH
5a-Cholest-8-en-3b-ol
NADP
NADPH
Lathosterol
NADP
7-Dehydrodesmosterol
7-Dehydrocholesterol
NADPH
NADP
Desmosterol
NADPH
O
2
NADP
H
2
O
NADPH
NADP
NADPH
NADP
Vitamin D3
8-Dehydrocholesterol
NADPH
NADP
CoA
Fatty acid
Cholesterol Ester
H
2
O
Fatty acid
H
2
O
Magnesium
Magnesium
Magnesium
Magnesium
Magnesium
Magnesium
FAD
FAD
Heme
FAD
Iron
FAD
FAD
Iron
FAD
FAD
Butyrate
Metabolism
Pyruvate
Metabolism
Valine,
Leucine, and
Isoleucine
Degradation
Tryptophan
Metabolism
Pyruvate
Metabolism
Fatty Acid
Metabolism
Steroidogenesis
Bile Acid
Biosynthesis
Endoplasmic Reticulum
Peroxisome
Peroxisome
Intracellular Space
Extracellular Space
Endoplasmic Reticulum
Lysosome
hv
Spontaneous isomeration