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GTP cyclohydrolase GTP cyclohydrolase GTP cyclohydrolase GTP cyclohydrolase 6-pyruvoyl tetrahydrobiopterin synthase Sepiapterin reductase Sepiapterin reductase Aldose reductase Carbonyl reductase [NADPH] 1 Sepiapterin reductase Carbonyl reductase [NADPH] 1 Sepiapterin reductase Dihydrofolate reductase Dihydropteridine reductase Sepiapterin reductase Guanosine triphosphate Formamidopyrimidine nucleoside triphosphate H2O 2,5-Diaminopyrimidine nucleoside triphosphate Formic acid H2O Formic acid 2,5-Diamino-6-(5'- triphosphoryl-3',4'- trihydroxy-2'-oxopentyl)- amino-4-oxopyrimidine Dihydroneopterin triphosphate H2O Dyspropterin PPPi NADP NADPH 1-hydroxy-2-Oxopropyl tetrahydropterin NADP 6-Lactoyltetrahydropterin NADPH NADP NADPH Sepiapterin NADPH 7,8-Dihydroneopterin NADP NADP NADPH NADP Tetrahydrobiopterin NADPH NADPH NADP H2O Neopterin NADP Dihydrobiopterin NADPH NAD NADH Zinc Zinc Zinc Zinc Zinc Purine Metabolism Intracellular space
GCH1 GCH1 GCH1 GCH1 PTS SPR SPR AKR1B1 CBR1 SPR CBR1 SPR DHFR QDPR SPR Guanosine triphosphate Formamidopyrimidine nucleoside triphosphate Water 2,5- Diaminopyrimidine nucleoside triphosphate Formic acid Water Formic acid 2,5-Diamino- 6-(5'- triphosphoryl- 3',4'- trihydroxy- 2'- oxopentyl)- amino-4- oxopyrimidine Dihydroneopterin triphosphate Water Dyspropterin PPPi NADP NADPH 1-hydroxy-2- Oxopropyl tetrahydropterin NADP 6- Lactoyltetrahydropterin NADPH NADP NADPH Sepiapterin NADPH 7,8- Dihydroneopterin NADP NADP NADPH NADP Tetrahydrobiopterin NADPH NADPH NADP Water Neopterin NADP Dihydrobiopterin NADPH NAD NADH Purine Metabolism
GCH1 GCH1 GCH1 GCH1 PTS SPR SPR AKR1B1 CBR1 SPR CBR1 SPR DHFR QDPR SPR GTP Formami H2O 25DNT Formate H2O Formate DTTOAO DHNTP H2O Dysprop PPPi NADP NADPH 1H2OT NADP 6-Lthpn NADPH NADP NADPH Sepiapt NADPH 7,8DHPN NADP NADP NADPH NADP BH4 NADPH NADPH NADP H2O Neopter NADP BH3 NADPH NAD NADH Zinc Zinc Zinc Zinc Zinc PW000052 Intracellular space
GCH1 GCH1 GCH1 GCH1 PTS SPR SPR AKR1B1 CBR1 SPR CBR1 SPR DHFR QDPR SPR GTP Formami H2O 25DNT Formate H2O Formate DTTOAO DHNTP H2O Dysprop PPPi NADP NADPH 1H2OT NADP 6-Lthpn NADPH NADP NADPH Sepiapt NADPH 7,8DHPN NADP NADP NADPH NADP BH4 NADPH NADPH NADP H2O Neopter NADP BH3 NADPH NAD NADH PW000052