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Estrogen
sulfotransferase
Retinol
dehydrogenase 8
UDP-
glucuronosyltransferase
3A1
Aromatase
Steroid 17-alpha-
hydroxylase/17,20
lyase
3-beta-HSD 1
Steroid 17-alpha-
hydroxylase/17,20
lyase
3-beta-HSD 1
Sulfotransferase
1A1
Aromatase
Very-long-chain
3-oxoacyl-CoA
reductase
Dihydrodiol
dehydrogenase 3
3-oxo-5-alpha-
steroid
4-dehydrogenase 1
UDP-
glucuronosyltransferase
3A1
Arylsulfatase A
17-
Hydroxyprogesterone
17a-
Hydroxypregnenolone
Estrone
Phosphoadenosine
phosphosulfate
Estrone sulfate
Adenosine
3',5'-diphosphate
19-Oxoandrost-
4-ene-3,17- dione
Estradiol
NADP
NADPH
19-
Oxotestosterone
19-
Hydroxyandrost-
4-ene-3,17- dione
19-
Hydroxytestosterone
Uridine
diphosphate
glucuronic acid
17-β-Estradiol-
3-glucuronide
Uridine
5'-diphosphate
Androstenedione
O
2
H
2
O
NAD
NADH
Dehydroepiandrosterone
NAD
NADH
Phosphoadenosine
phosphosulfate
Adenosine
3',5'-diphosphate
Dehydroepiandrosterone
sulfate
Testosterone
O
2
H
2
O
NAD
NADH
H
+
5b-
Dihydrotestosterone
Dihydrotestosterone
NADP
NADPH
H
+
Testosterone
glucuronide
H
2
O
Sulfate
Heme
Heme
Heme
Heme
Calcium
Reduced
flavoprotein
Oxidized
flavoprotein
Steroidogenesis
ER Membrane
ER Membrane
Cytoplasm
ER Lumen
ER Lumen
Smooth Endoplasmic Reticulum
Intracellular Space
Extracellular Space