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3-oxo-5-
alpha-steroid
4-dehydrogenase
1
Dihydrodiol
dehydrogenase 3
UDP-
glucuronosyltransferase
1-1
Aromatase
Aromatase
Aromatase
Very-long-chain
3-oxoacyl-CoA
reductase
Cytochrome P450
11B1,
mitochondrial
Dihydrodiol
dehydrogenase 3
UDP-
glucuronosyltransferase
1-1
Hydroxysteroid
11-beta-
dehydrogenase
1-like protein
Dihydrodiol
dehydrogenase 3
11b-
Hydroxyandrost-
4-ene-3,17-
dione
11b-
Hydroxyandrost-
4-ene-3,17-
dione
Androstenedione
NADPH
H
+
Androstanedione
NADP
NADH
H
+
Androsterone
NAD
Uridine
diphosphate
glucuronic acid
Androsterone
glucuronide
Uridine
5'-diphosphate
O
2
19-
Hydroxyandrost-
4-ene-3,17-
dione
H
2
O
O
2
19-
Oxoandrost-4-
ene-3,17- dione
H
2
O
O
2
Estrone
Formic acid
H
2
O
Testosterone
NAD
NADH
H
+
O
2
H
+
H
2
O
NADPH
H
+
NADP
Etiocholanedione
Etiocholanolone
Uridine
diphosphate
glucuronic acid
Etiocholanolone
glucuronide
Uridine
5'-diphosphate
NADP
NADPH
H
+
Adrenosterone
NADH
H
+
NAD
Heme
Reduced
flavoprotein
Oxidized
flavoprotein
Reduced
flavoprotein
Oxidized
flavoprotein
Reduced
flavoprotein
Oxidized
flavoprotein
Reduced adrenal
ferredoxin
Oxidized
adrenal
ferredoxin
Heme
Heme
Heme
Mitochondrial Inner Membrane
Mitochondrial Outer Membrane
Mitochondrial Matrix
Mitochondrial Intermembrane
Space
Endoplasmic Reticulum
Membrane
Cytosol
Endoplasmic Reticulum
Mitochondria
SRD5A1
Unknown
ERP29
CYP19A1
CYP19A1
CYP19A1
HSD17B12
CYP11B1
Unknown
ERP29
HSD11B1L
Unknown
11b-
Hydroxyandrost-
4-ene-3,17-
dione
11b-
Hydroxyandrost-
4-ene-3,17-
dione
Androstenedione
NADPH
Hydrogen Ion
Androstanedione
NADP
NADH
Hydrogen Ion
Androsterone
NAD
Uridine
diphosphate
glucuronic acid
Androsterone
glucuronide
Uridine
5'-diphosphate
Oxygen
19-
Hydroxyandrost-
4-ene-3,17-
dione
Water
Oxygen
19-
Oxoandrost-4-
ene-3,17- dione
Water
Oxygen
Estrone
Formic acid
Water
Testosterone
NAD
NADH
Hydrogen Ion
Oxygen
Hydrogen Ion
Water
NADPH
Hydrogen Ion
NADP
Etiocholanedione
Etiocholanolone
Uridine
diphosphate
glucuronic acid
Etiocholanolone
glucuronide
Uridine
5'-diphosphate
NADP
NADPH
Hydrogen Ion
Adrenosterone
NADH
Hydrogen Ion
NAD
Reduced
flavoprotein
Oxidized
flavoprotein
Reduced
flavoprotein
Oxidized
flavoprotein
Reduced
flavoprotein
Oxidized
flavoprotein
Reduced adrenal
ferredoxin
Oxidized
adrenal
ferredoxin