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Pathway Description
Estrone Metabolism
Bos taurus
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2018-08-10
Last Updated: 2019-08-16
Estrone (also known as oestrone) is a weak endogenous estrogen, a steroid and minor female sex hormone. Estrone is synthesized from cholesterol and secreted from gonads. Endoplasmic reticulum (ER) is the place that estrone undergoes primary metabolism. Estrone sulfate and estrone glucuronide are the conjugated product of estrone; and CYP450 can hydroxylate estrone into catechol estrogens. The enzyme catechol O-methyltransferase catalyzes the conversion of 2-hydroxyestrone into 2-methoxyestrone which is used to synthesize 2-methoxyestrone 3-glucuronide via the membrane-associated massive multimer UDP-glucuronosyltransferase 1-1. Estrone can also be reversibly converted into estradiol by estradiol 17-beta-dehydrogenase 1. This same enzyme can reversibly convert 16a-hydroxyestrone (synthesized from estrone via cytochrome P450 3A5) into estriol. Estriol is alternatively synthesized from estradiol via cytochrome P450 3A5.
References
Estrone Metabolism References
Nash AR, Glenn WK, Moore SS, Kerr J, Thompson AR, Thompson EO: Oestrogen sulfotransferase: molecular cloning and sequencing of cDNA for the bovine placental enzyme. Aust J Biol Sci. 1988;41(4):507-16.
Pubmed: 3271383
Moore SS, Thompson EO, Nash AR: Oestrogen sulfotransferase: isolation of a high specific activity species from bovine placenta. Aust J Biol Sci. 1988;41(3):333-41.
Pubmed: 3270501
Adams JB: Enzymic synthesis of steroid sulphates. XVII. On the structure of bovine estrogen sulphotransferase. Biochim Biophys Acta. 1991 Jan 29;1076(2):282-8. doi: 10.1016/0167-4838(91)90279-9.
Pubmed: 1900200
Harhay GP, Sonstegard TS, Keele JW, Heaton MP, Clawson ML, Snelling WM, Wiedmann RT, Van Tassell CP, Smith TP: Characterization of 954 bovine full-CDS cDNA sequences. BMC Genomics. 2005 Nov 23;6:166. doi: 10.1186/1471-2164-6-166.
Pubmed: 16305752
Yamauchi K, Yamamoto T, Hayashi H, Koya S, Takikawa H, Toyoshima K, Horiuchi R: Sequence of membrane-associated thyroid hormone binding protein from bovine liver: its identity with protein disulphide isomerase. Biochem Biophys Res Commun. 1987 Aug 14;146(3):1485-92. doi: 10.1016/0006-291x(87)90817-5.
Pubmed: 3619939
Wetterau JR, Combs KA, Spinner SN, Joiner BJ: Protein disulfide isomerase is a component of the microsomal triglyceride transfer protein complex. J Biol Chem. 1990 Jun 15;265(17):9800-7.
Pubmed: 2351674
Galat A, Bouet F: Cyclophilin-B is an abundant protein whose conformation is similar to cyclophilin-A. FEBS Lett. 1994 Jun 20;347(1):31-6. doi: 10.1016/0014-5793(94)00501-x.
Pubmed: 8013656
Bose S, Mucke M, Freedman RB: The characterization of a cyclophilin-type peptidyl prolyl cis-trans-isomerase from the endoplasmic-reticulum lumen. Biochem J. 1994 Jun 15;300 ( Pt 3):871-5. doi: 10.1042/bj3000871.
Pubmed: 8010972
Ferrari DM, Nguyen Van P, Kratzin HD, Soling HD: ERp28, a human endoplasmic-reticulum-lumenal protein, is a member of the protein disulfide isomerase family but lacks a CXXC thioredoxin-box motif. Eur J Biochem. 1998 Aug 1;255(3):570-9. doi: 10.1046/j.1432-1327.1998.2550570.x.
Pubmed: 9738895
Rattner A, Smallwood PM, Nathans J: Identification and characterization of all-trans-retinol dehydrogenase from photoreceptor outer segments, the visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol. J Biol Chem. 2000 Apr 14;275(15):11034-43. doi: 10.1074/jbc.275.15.11034.
Pubmed: 10753906
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0030880
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