Loading Pathway...
Error: Pathway image not found.
Hide
Pathway Description
Estrone Metabolism
Rattus norvegicus
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2018-08-10
Last Updated: 2019-08-16
Estrone (also known as oestrone) is a weak endogenous estrogen, a steroid and minor female sex hormone. Estrone is synthesized from cholesterol and secreted from gonads. Endoplasmic reticulum (ER) is the place that estrone undergoes primary metabolism. Estrone sulfate and estrone glucuronide are the conjugated product of estrone; and CYP450 can hydroxylate estrone into catechol estrogens. The enzyme catechol O-methyltransferase catalyzes the conversion of 2-hydroxyestrone into 2-methoxyestrone which is used to synthesize 2-methoxyestrone 3-glucuronide via the membrane-associated massive multimer UDP-glucuronosyltransferase 1-1. Estrone can also be reversibly converted into estradiol by estradiol 17-beta-dehydrogenase 1. This same enzyme can reversibly convert 16a-hydroxyestrone (synthesized from estrone via cytochrome P450 3A5) into estriol. Estriol is alternatively synthesized from estradiol via cytochrome P450 3A5.
References
Estrone Metabolism References
Rikke BA, Roy AK: Structural relationships among members of the mammalian sulfotransferase gene family. Biochim Biophys Acta. 1996 Jul 17;1307(3):331-8. doi: 10.1016/0167-4781(96)00065-6.
Pubmed: 8688469
Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun. 2012 Jun 6;3:876. doi: 10.1038/ncomms1871.
Pubmed: 22673903
Sogawa K, Gotoh O, Kawajiri K, Fujii-Kuriyama Y: Distinct organization of methylcholanthrene- and phenobarbital-inducible cytochrome P-450 genes in the rat. Proc Natl Acad Sci U S A. 1984 Aug;81(16):5066-70. doi: 10.1073/pnas.81.16.5066.
Pubmed: 6089174
Yabusaki Y, Shimizu M, Murakami H, Nakamura K, Oeda K, Ohkawa H: Nucleotide sequence of a full-length cDNA coding for 3-methylcholanthrene-induced rat liver cytochrome P-450MC. Nucleic Acids Res. 1984 Mar 26;12(6):2929-38. doi: 10.1093/nar/12.6.2929.
Pubmed: 6324135
Hines RN, Levy JB, Conrad RD, Iversen PL, Shen ML, Renli AM, Bresnick E: Gene structure and nucleotide sequence for rat cytochrome P-450c. Arch Biochem Biophys. 1985 Mar;237(2):465-76. doi: 10.1016/0003-9861(85)90300-5.
Pubmed: 3838427
Tenhunen J, Ulmanen I: Production of rat soluble and membrane-bound catechol O-methyltransferase forms from bifunctional mRNAs. Biochem J. 1993 Dec 15;296 ( Pt 3):595-600. doi: 10.1042/bj2960595.
Pubmed: 8280056
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. doi: 10.1101/gr.2596504.
Pubmed: 15489334
Salminen M, Lundstrom K, Tilgmann C, Savolainen R, Kalkkinen N, Ulmanen I: Molecular cloning and characterization of rat liver catechol-O-methyltransferase. Gene. 1990 Sep 14;93(2):241-7. doi: 10.1016/0378-1119(90)90231-f.
Pubmed: 2227437
Meunier L, Usherwood YK, Chung KT, Hendershot LM: A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins. Mol Biol Cell. 2002 Dec;13(12):4456-69. doi: 10.1091/mbc.e02-05-0311.
Pubmed: 12475965
Munro S, Pelham HR: An Hsp70-like protein in the ER: identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein. Cell. 1986 Jul 18;46(2):291-300. doi: 10.1016/0092-8674(86)90746-4.
Pubmed: 3087629
Chang SC, Wooden SK, Nakaki T, Kim YK, Lin AY, Kung L, Attenello JW, Lee AS: Rat gene encoding the 78-kDa glucose-regulated protein GRP78: its regulatory sequences and the effect of protein glycosylation on its expression. Proc Natl Acad Sci U S A. 1987 Feb;84(3):680-4. doi: 10.1073/pnas.84.3.680.
Pubmed: 3468506
Edman JC, Ellis L, Blacher RW, Roth RA, Rutter WJ: Sequence of protein disulphide isomerase and implications of its relationship to thioredoxin. Nature. 1985 Sep 19-25;317(6034):267-70. doi: 10.1038/317267a0.
Pubmed: 3840230
Yokoi T, Nagayama S, Kajiwara R, Kawaguchi Y, Horiuchi R, Kamataki T: Identification of protein disulfide isomerase and calreticulin as autoimmune antigens in LEC strain of rats. Biochim Biophys Acta. 1993 Nov 28;1158(3):339-44. doi: 10.1016/0304-4165(93)90033-5.
Pubmed: 8251535
Van PN, Rupp K, Lampen A, Soling HD: CaBP2 is a rat homolog of ERp72 with proteindisulfide isomerase activity. Eur J Biochem. 1993 Apr 15;213(2):789-95. doi: 10.1111/j.1432-1033.1993.tb17821.x.
Pubmed: 8477750
Fullekrug J, Sonnichsen B, Wunsch U, Arseven K, Nguyen Van P, Soling HD, Mieskes G: CaBP1, a calcium binding protein of the thioredoxin family, is a resident KDEL protein of the ER and not of the intermediate compartment. J Cell Sci. 1994 Oct;107 ( Pt 10):2719-27.
Pubmed: 7876340
Iwai N, Inagami T: Molecular cloning of a complementary DNA to rat cyclophilin-like protein mRNA. Kidney Int. 1990 Jun;37(6):1460-5. doi: 10.1038/ki.1990.136.
Pubmed: 2194066
Arber S, Krause KH, Caroni P: s-cyclophilin is retained intracellularly via a unique COOH-terminal sequence and colocalizes with the calcium storage protein calreticulin. J Cell Biol. 1992 Jan;116(1):113-25. doi: 10.1083/jcb.116.1.113.
Pubmed: 1530944
Kainer DB, Doris PA: Cyclophilin B expression in renal proximal tubules of hypertensive rats. Hypertension. 2000 Apr;35(4):958-64. doi: 10.1161/01.hyp.35.4.958.
Pubmed: 10775569
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0030880
Highlighted elements will appear in red.
Highlight Compounds
Highlight Proteins
Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.
Visualize Compound Data
Visualize Protein Data
Downloads
Settings