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Pathway Description
Glutamate Metabolism
Caenorhabditis elegans
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2018-08-10
Last Updated: 2019-08-16
Glutamate is one of the non-essential amino acids that is produced by the body. Glutamate is precursor for many nucleic acids and proteins in addition to its role in the central nervous system. It is an excitatory neurotransmitter and has a role in neuronal plasticity, affecting memory and learning. Glutamate plays a role in numerous metabolic pathways. Dysfunctional glutamate metabolism may cause disorders such as: gyrate atrophy, hyperammonemia, γ-hydoxybutyric aciduria, hemolytic anemia, and 5-oxoprolinuria.
References
Glutamate Metabolism References
Genome sequence of the nematode C. elegans: a platform for investigating biology. Science. 1998 Dec 11;282(5396):2012-8. doi: 10.1126/science.282.5396.2012.
Pubmed: 9851916
Mio T, Yamada-Okabe T, Arisawa M, Yamada-Okabe H: Saccharomyces cerevisiae GNA1, an essential gene encoding a novel acetyltransferase involved in UDP-N-acetylglucosamine synthesis. J Biol Chem. 1999 Jan 1;274(1):424-9. doi: 10.1074/jbc.274.1.424.
Pubmed: 9867860
Franks DM, Izumikawa T, Kitagawa H, Sugahara K, Okkema PG: C. elegans pharyngeal morphogenesis requires both de novo synthesis of pyrimidines and synthesis of heparan sulfate proteoglycans. Dev Biol. 2006 Aug 15;296(2):409-20. doi: 10.1016/j.ydbio.2006.06.008. Epub 2006 Jun 8.
Pubmed: 16828468
Levitte S, Salesky R, King B, Coe Smith S, Depper M, Cole M, Hermann GJ: A Caenorhabditis elegans model of orotic aciduria reveals enlarged lysosome-related organelles in embryos lacking umps-1 function. FEBS J. 2010 Mar;277(6):1420-39. doi: 10.1111/j.1742-4658.2010.07573.x. Epub 2010 Feb 10.
Pubmed: 20148972
Chitturi J, Hung W, Rahman AMA, Wu M, Lim MA, Calarco J, Baran R, Huang X, Dennis JW, Zhen M: The UBR-1 ubiquitin ligase regulates glutamate metabolism to generate coordinated motor pattern in Caenorhabditis elegans. PLoS Genet. 2018 Apr 12;14(4):e1007303. doi: 10.1371/journal.pgen.1007303. eCollection 2018 Apr.
Pubmed: 29649217
Inoue H, Hisamoto N, An JH, Oliveira RP, Nishida E, Blackwell TK, Matsumoto K: The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response. Genes Dev. 2005 Oct 1;19(19):2278-83. doi: 10.1101/gad.1324805. Epub 2005 Sep 15.
Pubmed: 16166371
Hoeven Rv, McCallum KC, Cruz MR, Garsin DA: Ce-Duox1/BLI-3 generated reactive oxygen species trigger protective SKN-1 activity via p38 MAPK signaling during infection in C. elegans. PLoS Pathog. 2011 Dec;7(12):e1002453. doi: 10.1371/journal.ppat.1002453. Epub 2011 Dec 22.
Pubmed: 22216003
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000072
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