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Pathway Description
Ammonia Recycling
Caenorhabditis elegans
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2018-08-10
Last Updated: 2019-08-16
Ammonia can be rerouted from the urine and recycled into the body for use in nitrogen metabolism. Glutamate and glutamine play an important role in this process. There are many other processes that act to recycle ammonia. asparaginase recycles ammonia from asparagine. Glycine cleavage system generates ammonia from glycine. Histidine ammonia lyase forms ammonia from histidine. Serine dehydratase also produces ammonia by cleaving serine.
References
Ammonia Recycling References
Genome sequence of the nematode C. elegans: a platform for investigating biology. Science. 1998 Dec 11;282(5396):2012-8. doi: 10.1126/science.282.5396.2012.
Pubmed: 9851916
Murphy JT, Bruinsma JJ, Schneider DL, Collier S, Guthrie J, Chinwalla A, Robertson JD, Mardis ER, Kornfeld K: Histidine protects against zinc and nickel toxicity in Caenorhabditis elegans. PLoS Genet. 2011 Mar;7(3):e1002013. doi: 10.1371/journal.pgen.1002013. Epub 2011 Mar 24.
Pubmed: 21455490
Franks DM, Izumikawa T, Kitagawa H, Sugahara K, Okkema PG: C. elegans pharyngeal morphogenesis requires both de novo synthesis of pyrimidines and synthesis of heparan sulfate proteoglycans. Dev Biol. 2006 Aug 15;296(2):409-20. doi: 10.1016/j.ydbio.2006.06.008. Epub 2006 Jun 8.
Pubmed: 16828468
Levitte S, Salesky R, King B, Coe Smith S, Depper M, Cole M, Hermann GJ: A Caenorhabditis elegans model of orotic aciduria reveals enlarged lysosome-related organelles in embryos lacking umps-1 function. FEBS J. 2010 Mar;277(6):1420-39. doi: 10.1111/j.1742-4658.2010.07573.x. Epub 2010 Feb 10.
Pubmed: 20148972
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000009
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