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Pathway Description
beta-Alanine Metabolism
Caenorhabditis elegans
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2018-08-10
Last Updated: 2019-08-30
Beta-alanine, 3-aminopropanoic acid, is a non-essential amino acid. Beta-Alanine is formed by the proteolytic degradation of beta-alanine containing dipeptides: carnosine, anserine, balenine, and pantothenic acid (vitamin B5). These dipeptides are consumed from protein-rich foods such as chicken, beef, pork, and fish. Beta-Alanine can also be formed in the liver from the breakdown of pyrimidine nucleotides into uracil and dihydrouracil and then metabolized into beta-alanine and beta-aminoisobutyrate. Beta-Alanine can also be formed via the action of aldehyde dehydrogenase on beta-aminoproionaldehyde which is generated from various aliphatic polyamines. Under normal conditions, beta-alanine is metabolized to aspartic acid through the action of glutamate decarboxylase. It addition, it can be converted to malonate semialdehyde and thereby participate in propanoate metabolism. Beta-Alanine is not a proteogenic amino acid. This amino acid is a common athletic supplementation due to its belief to improve performance by increased muscle carnosine levels.
References
beta-Alanine Metabolism References
Genome sequence of the nematode C. elegans: a platform for investigating biology. Science. 1998 Dec 11;282(5396):2012-8. doi: 10.1126/science.282.5396.2012.
Pubmed: 9851916
Alkema MJ, Hunter-Ensor M, Ringstad N, Horvitz HR: Tyramine Functions independently of octopamine in the Caenorhabditis elegans nervous system. Neuron. 2005 Apr 21;46(2):247-60. doi: 10.1016/j.neuron.2005.02.024.
Pubmed: 15848803
Burkewitz K, Morantte I, Weir HJM, Yeo R, Zhang Y, Huynh FK, Ilkayeva OR, Hirschey MD, Grant AR, Mair WB: Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal. Cell. 2015 Feb 26;160(5):842-855. doi: 10.1016/j.cell.2015.02.004.
Pubmed: 25723162
Takemoto T, Sasaki Y, Hamajima N, Goshima Y, Nonaka M, Kimura H: Cloning and characterization of the Caenorhabditis elegans CeCRMP/DHP-1 and -2; common ancestors of CRMP and dihydropyrimidinase? Gene. 2000 Dec 31;261(2):259-67. doi: 10.1016/s0378-1119(00)00494-7.
Pubmed: 11167013
Byk T, Ozon S, Sobel A: The Ulip family phosphoproteins--common and specific properties. Eur J Biochem. 1998 May 15;254(1):14-24. doi: 10.1046/j.1432-1327.1998.2540014.x.
Pubmed: 9652388
Kim S, Park DH, Shim J: Thymidylate synthase and dihydropyrimidine dehydrogenase levels are associated with response to 5-fluorouracil in Caenorhabditis elegans. Mol Cells. 2008 Oct 31;26(4):344-9. Epub 2008 Jul 9.
Pubmed: 18612238
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000007
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