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Pathway Description
Estrone Metabolism
Caenorhabditis elegans
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2018-08-10
Last Updated: 2019-08-16
Estrone (also known as oestrone) is a weak endogenous estrogen, a steroid and minor female sex hormone. Estrone is synthesized from cholesterol and secreted from gonads. Endoplasmic reticulum (ER) is the place that estrone undergoes primary metabolism. Estrone sulfate and estrone glucuronide are the conjugated product of estrone; and CYP450 can hydroxylate estrone into catechol estrogens. The enzyme catechol O-methyltransferase catalyzes the conversion of 2-hydroxyestrone into 2-methoxyestrone which is used to synthesize 2-methoxyestrone 3-glucuronide via the membrane-associated massive multimer UDP-glucuronosyltransferase 1-1. Estrone can also be reversibly converted into estradiol by estradiol 17-beta-dehydrogenase 1. This same enzyme can reversibly convert 16a-hydroxyestrone (synthesized from estrone via cytochrome P450 3A5) into estriol. Estriol is alternatively synthesized from estradiol via cytochrome P450 3A5.
References
Estrone Metabolism References
Genome sequence of the nematode C. elegans: a platform for investigating biology. Science. 1998 Dec 11;282(5396):2012-8. doi: 10.1126/science.282.5396.2012.
Pubmed: 9851916
Heschl MF, Baillie DL: Characterization of the hsp70 multigene family of Caenorhabditis elegans. DNA. 1989 May;8(4):233-43.
Pubmed: 2766926
Truttmann MC, Cruz VE, Guo X, Engert C, Schwartz TU, Ploegh HL: The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones. PLoS Genet. 2016 May 3;12(5):e1006023. doi: 10.1371/journal.pgen.1006023. eCollection 2016 May.
Pubmed: 27138431
Veijola J, Annunen P, Koivunen P, Page AP, Pihlajaniemi T, Kivirikko KI: Baculovirus expression of two protein disulphide isomerase isoforms from Caenorhabditis elegans and characterization of prolyl 4-hydroxylases containing one of these polypeptides as their beta subunit. Biochem J. 1996 Aug 1;317 ( Pt 3):721-9. doi: 10.1042/bj3170721.
Pubmed: 8760355
Winter AD, Page AP: Prolyl 4-hydroxylase is an essential procollagen-modifying enzyme required for exoskeleton formation and the maintenance of body shape in the nematode Caenorhabditis elegans. Mol Cell Biol. 2000 Jun;20(11):4084-93. doi: 10.1128/mcb.20.11.4084-4093.2000.
Pubmed: 10805750
Wilson R, Ainscough R, Anderson K, Baynes C, Berks M, Bonfield J, Burton J, Connell M, Copsey T, Cooper J, et al.: 2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans. Nature. 1994 Mar 3;368(6466):32-8. doi: 10.1038/368032a0.
Pubmed: 7906398
Eletto D, Eletto D, Dersh D, Gidalevitz T, Argon Y: Protein disulfide isomerase A6 controls the decay of IRE1alpha signaling via disulfide-dependent association. Mol Cell. 2014 Feb 20;53(4):562-576. doi: 10.1016/j.molcel.2014.01.004. Epub 2014 Feb 6.
Pubmed: 24508390
Page AP, MacNiven K, Hengartner MO: Cloning and biochemical characterization of the cyclophilin homologues from the free-living nematode Caenorhabditis elegans. Biochem J. 1996 Jul 1;317 ( Pt 1):179-85. doi: 10.1042/bj3170179.
Pubmed: 8694762
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0030880
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