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Pathway Description
Bile Acid Direct Signalling Pathway (2)
Homo sapiens
Category:
Metabolite Pathway
Sub-Category:
Signaling
Created: 2018-08-14
Last Updated: 2019-08-16
In the intestine, L-cells (enteroendocrine cells) can produce glucagon-like peptide 1 (GLP-1) after bile acid activates G-protein coupled bile acid receptor 1 on L-cells. Only small portion of GLP-1 can enter the systemic cirulation, and most of GLP-1 are degraded by dipeptidyl peptidase-4. Therefore, only small portion of GLP-1 can eventually across blood-brain barrier to interact with GLP-1 receptors
References
Bile Acid Direct Signalling Pathway (2) References
Shapiro H, Kolodziejczyk AA, Halstuch D, Elinav E: Bile acids in glucose metabolism in health and disease. J Exp Med. 2018 Feb 5;215(2):383-396. doi: 10.1084/jem.20171965. Epub 2018 Jan 16.
Pubmed: 29339445
Mertens KL, Kalsbeek A, Soeters MR, Eggink HM: Bile Acid Signaling Pathways from the Enterohepatic Circulation to the Central Nervous System. Front Neurosci. 2017 Nov 7;11:617. doi: 10.3389/fnins.2017.00617. eCollection 2017.
Pubmed: 29163019
Oelkers P, Kirby LC, Heubi JE, Dawson PA: Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2). J Clin Invest. 1997 Apr 15;99(8):1880-7. doi: 10.1172/JCI119355.
Pubmed: 9109432
Love MW, Craddock AL, Angelin B, Brunzell JD, Duane WC, Dawson PA: Analysis of the ileal bile acid transporter gene, SLC10A2, in subjects with familial hypertriglyceridemia. Arterioscler Thromb Vasc Biol. 2001 Dec;21(12):2039-45.
Pubmed: 11742882
Wong MH, Oelkers P, Dawson PA: Identification of a mutation in the ileal sodium-dependent bile acid transporter gene that abolishes transport activity. J Biol Chem. 1995 Nov 10;270(45):27228-34. doi: 10.1074/jbc.270.45.27228.
Pubmed: 7592981
Maruyama T, Miyamoto Y, Nakamura T, Tamai Y, Okada H, Sugiyama E, Nakamura T, Itadani H, Tanaka K: Identification of membrane-type receptor for bile acids (M-BAR). Biochem Biophys Res Commun. 2002 Nov 15;298(5):714-9. doi: 10.1016/s0006-291x(02)02550-0.
Pubmed: 12419312
Kawamata Y, Fujii R, Hosoya M, Harada M, Yoshida H, Miwa M, Fukusumi S, Habata Y, Itoh T, Shintani Y, Hinuma S, Fujisawa Y, Fujino M: A G protein-coupled receptor responsive to bile acids. J Biol Chem. 2003 Mar 14;278(11):9435-40. doi: 10.1074/jbc.M209706200. Epub 2003 Jan 10.
Pubmed: 12524422
Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S: Identification of G protein-coupled receptor genes from the human genome sequence. FEBS Lett. 2002 Jun 5;520(1-3):97-101. doi: 10.1016/s0014-5793(02)02775-8.
Pubmed: 12044878
Thorens B, Porret A, Buhler L, Deng SP, Morel P, Widmann C: Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor. Diabetes. 1993 Nov;42(11):1678-82. doi: 10.2337/diab.42.11.1678.
Pubmed: 8405712
Dillon JS, Tanizawa Y, Wheeler MB, Leng XH, Ligon BB, Rabin DU, Yoo-Warren H, Permutt MA, Boyd AE 3rd: Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor. Endocrinology. 1993 Oct;133(4):1907-10. doi: 10.1210/endo.133.4.8404634.
Pubmed: 8404634
Graziano MP, Hey PJ, Borkowski D, Chicchi GG, Strader CD: Cloning and functional expression of a human glucagon-like peptide-1 receptor. Biochem Biophys Res Commun. 1993 Oct 15;196(1):141-6. doi: 10.1006/bbrc.1993.2226.
Pubmed: 8216285
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