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Pathway Description
p53 Signaling Pathway
Mus musculus
Category:
Metabolite Pathway
Sub-Category:
Signaling
Created: 2018-08-23
Last Updated: 2019-09-15
p53, named for its apparent molecular mass of 53 kilodaltons via SDS-PAGE analysis, is a protein that functions as a tumour suppressor and plays an important role in cell cycle regulation and cancer prevention. Over 50% of all cancers are theorized to involve p53-inactivating mutations. DNA damage, activated oncogenes, and oxidative stress can all produce stress signals to activate the p53 protein which is a transcriptional activator of >2500 p53-regulated genes. Activation of p53-regulated genes will lead to cellular senescence, cell cycle arrest, or apoptosis. Activated p53-regulated genes will also communicate with nearby cells for the purpose of DNA repair or feedback loop set-up that can either strengthen or weaken the stress responses of the p53 protein.
References
p53 Signaling Pathway References
Oltvai ZN, Milliman CL, Korsmeyer SJ: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 1993 Aug 27;74(4):609-19. doi: 10.1016/0092-8674(93)90509-o.
Pubmed: 8358790
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Pubmed: 15489334
Nam YJ, Mani K, Ashton AW, Peng CF, Krishnamurthy B, Hayakawa Y, Lee P, Korsmeyer SJ, Kitsis RN: Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions. Mol Cell. 2004 Sep 24;15(6):901-12. doi: 10.1016/j.molcel.2004.08.020.
Pubmed: 15383280
Deng X, Ito T, Carr B, Mumby M, May WS Jr: Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A. J Biol Chem. 1998 Dec 18;273(51):34157-63. doi: 10.1074/jbc.273.51.34157.
Pubmed: 9852076
Negrini M, Silini E, Kozak C, Tsujimoto Y, Croce CM: Molecular analysis of mbcl-2: structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma. Cell. 1987 May 22;49(4):455-63. doi: 10.1016/0092-8674(87)90448-x.
Pubmed: 3032455
Eguchi Y, Ewert DL, Tsujimoto Y: Isolation and characterization of the chicken bcl-2 gene: expression in a variety of tissues including lymphoid and neuronal organs in adult and embryo. Nucleic Acids Res. 1992 Aug 25;20(16):4187-92. doi: 10.1093/nar/20.16.4187.
Pubmed: 1508712
Huppi K, Siwarski D, Dosik J, Michieli P, Chedid M, Reed S, Mock B, Givol D, Mushinski JF: Molecular cloning, sequencing, chromosomal localization and expression of mouse p21 (Waf1). Oncogene. 1994 Oct;9(10):3017-20.
Pubmed: 8084607
el-Deiry WS, Tokino T, Waldman T, Oliner JD, Velculescu VE, Burrell M, Hill DE, Healy E, Rees JL, Hamilton SR, et al.: Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues. Cancer Res. 1995 Jul 1;55(13):2910-9.
Pubmed: 7796420
Chapman DL, Wolgemuth DJ: Identification of a mouse B-type cyclin which exhibits developmentally regulated expression in the germ line. Mol Reprod Dev. 1992 Nov;33(3):259-69. doi: 10.1002/mrd.1080330305.
Pubmed: 1280449
Paterno GD, Downs KM: Sequence of a cDNA encoding a mouse cyclin B protein. Gene. 1991 Dec 15;108(2):315-6. doi: 10.1016/0378-1119(91)90454-j.
Pubmed: 1836195
Hanley-Hyde J, Mushinski JF, Sadofsky M, Huppi K, Krall M, Kozak CA, Mock B: Expression of murine cyclin B1 mRNAs and genetic mapping of related genomic sequences. Genomics. 1992 Aug;13(4):1018-30.
Pubmed: 1387105
Santamaria D, Barriere C, Cerqueira A, Hunt S, Tardy C, Newton K, Caceres JF, Dubus P, Malumbres M, Barbacid M: Cdk1 is sufficient to drive the mammalian cell cycle. Nature. 2007 Aug 16;448(7155):811-5. doi: 10.1038/nature06046.
Pubmed: 17700700
Satyanarayana A, Hilton MB, Kaldis P: p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint. Mol Biol Cell. 2008 Jan;19(1):65-77. doi: 10.1091/mbc.e07-06-0525. Epub 2007 Oct 17.
Pubmed: 17942597
Th'ng JP, Wright PS, Hamaguchi J, Lee MG, Norbury CJ, Nurse P, Bradbury EM: The FT210 cell line is a mouse G2 phase mutant with a temperature-sensitive CDC2 gene product. Cell. 1990 Oct 19;63(2):313-24. doi: 10.1016/0092-8674(90)90164-a.
Pubmed: 2208288
Balliet AG, Hatton KS, Hoffman B, Liebermann DA: Comparative analysis of the genetic structure and chromosomal location of the murine MyD118 (Gadd45beta) gene. DNA Cell Biol. 2001 Apr;20(4):239-47. doi: 10.1089/104454901750219125.
Pubmed: 11403721
Abdollahi A, Lord KA, Hoffman-Liebermann B, Liebermann DA: Sequence and expression of a cDNA encoding MyD118: a novel myeloid differentiation primary response gene induced by multiple cytokines. Oncogene. 1991 Jan;6(1):165-7.
Pubmed: 1899477
Jin R, De Smaele E, Zazzeroni F, Nguyen DU, Papa S, Jones J, Cox C, Gelinas C, Franzoso G: Regulation of the gadd45beta promoter by NF-kappaB. DNA Cell Biol. 2002 Jul;21(7):491-503. doi: 10.1089/104454902320219059.
Pubmed: 12162804
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0063782
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