Loading Pathway...
Error: Pathway image not found.
Hide
Pathway Description
p53 Signaling Pathway
Bos taurus
Category:
Metabolite Pathway
Sub-Category:
Signaling
Created: 2018-08-23
Last Updated: 2019-09-15
p53, named for its apparent molecular mass of 53 kilodaltons via SDS-PAGE analysis, is a protein that functions as a tumour suppressor and plays an important role in cell cycle regulation and cancer prevention. Over 50% of all cancers are theorized to involve p53-inactivating mutations. DNA damage, activated oncogenes, and oxidative stress can all produce stress signals to activate the p53 protein which is a transcriptional activator of >2500 p53-regulated genes. Activation of p53-regulated genes will lead to cellular senescence, cell cycle arrest, or apoptosis. Activated p53-regulated genes will also communicate with nearby cells for the purpose of DNA repair or feedback loop set-up that can either strengthen or weaken the stress responses of the p53 protein.
References
p53 Signaling Pathway References
Reyes RA, Cockerell GL: Increased ratio of bcl-2/bax expression is associated with bovine leukemia virus-induced leukemogenesis in cattle. Virology. 1998 Mar 1;242(1):184-92. doi: 10.1006/viro.1998.9029.
Pubmed: 9501056
Yang L, Farin CE: Identification of cDNAs encoding bovine cyclin B and Cdk1/Cdc2. Gene. 1994 Apr 20;141(2):283-6. doi: 10.1016/0378-1119(94)90586-x.
Pubmed: 8163203
Harhay GP, Sonstegard TS, Keele JW, Heaton MP, Clawson ML, Snelling WM, Wiedmann RT, Van Tassell CP, Smith TP: Characterization of 954 bovine full-CDS cDNA sequences. BMC Genomics. 2005 Nov 23;6:166. doi: 10.1186/1471-2164-6-166.
Pubmed: 16305752
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marcais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL: A whole-genome assembly of the domestic cow, Bos taurus. Genome Biol. 2009;10(4):R42. doi: 10.1186/gb-2009-10-4-r42. Epub 2009 Apr 24.
Pubmed: 19393038
Dequiedt F, Willems L, Burny A, Kettmann R: Nucleotide sequence of the bovine P53 tumor-suppressor cDNA. DNA Seq. 1995;5(4):261-4.
Pubmed: 7626789
Komori H, Ishiguro N, Horiuchi M, Shinagawa M, Aida Y: Predominant p53 mutations in enzootic bovine leukemic cell lines. Vet Immunol Immunopathol. 1996 Jun 15;52(1-2):53-63.
Pubmed: 8807776
Su S, Dehnade F, Zafarullah M: Regulation of tissue inhibitor of metalloproteinases-3 gene expression by transforming growth factor-beta and dexamethasone in bovine and human articular chondrocytes. DNA Cell Biol. 1996 Dec;15(12):1039-48. doi: 10.1089/dna.1996.15.1039.
Pubmed: 8985117
Balcerzak D, Querengesser L, Dixon WT, Baracos VE: Coordinate expression of matrix-degrading proteinases and their activators and inhibitors in bovine skeletal muscle. J Anim Sci. 2001 Jan;79(1):94-107. doi: 10.2527/2001.79194x.
Pubmed: 11204721
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0063782
Highlighted elements will appear in red.
Highlight Compounds
Highlight Proteins
Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.
Visualize Compound Data
Visualize Protein Data
Downloads
Settings