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Pathway Description
TNF/Stress Related Signaling
Bos taurus
Category:
Metabolite Pathway
Sub-Category:
Signaling
Created: 2018-08-23
Last Updated: 2019-08-16
Tumour necrosis factor alpha (TNF-a) is a cytokine that activates TNF rector 1 (TNFR1) signalling complex. TNFR1 mediates cell death signalling and inflammation in response to cytokines, bacteria and cellular stress. The classical NFkB pathway involves activation of TNF receptor associated factor 2, receptor interacting serine/threonine protein kinase and death domains which activate the IKK complex, phosphorylating the IKB proteins triggering their degradation resulting in NF-kB dimers dissociation and release. Caspase 2 interacts with TNF-receptor associated factor 2 and receptor interacting serine/threonine protein kinase to activate NFkB. Mitogen activated protein kinases of the MAP3K family are also involved in TNFR1-mediated IKK activation. Mitogen activated kinases can phosphorylate IKK to activate it as well. Activation of Mitogen-activated protein kinase 8 and 14 are involved in the cross-talk of other inflammatory pathways.
References
TNF/Stress Related Signaling References
Mertens B, Muriuki C, Gaidulis L: Cloning of two members of the TNF-superfamily in cattle: CD40 ligand and tumor necrosis factor alpha. Immunogenetics. 1995;42(5):430-1.
Pubmed: 7590981
Cludts I, Cleuter Y, Kettmann R, Burny A, Droogmans L: Cloning and characterization of the tandemly arranged bovine lymphotoxin and tumour necrosis factor-alpha genes. Cytokine. 1993 Jul;5(4):336-41.
Pubmed: 8260599
Dietz AB, Neibergs HL, Womack JE, Kehrli ME Jr: Rapid communication: single strand conformational polymorphism (SSCP) of bovine tumor necrosis factor alpha. J Anim Sci. 1997 Sep;75(9):2567. doi: 10.2527/1997.7592567x.
Pubmed: 9303477
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marcais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL: A whole-genome assembly of the domestic cow, Bos taurus. Genome Biol. 2009;10(4):R42. doi: 10.1186/gb-2009-10-4-r42. Epub 2009 Apr 24.
Pubmed: 19393038
Connor EE, Cates EA, Williams JL, Bannerman DD: Cloning and radiation hybrid mapping of bovine toll-like receptor-4 (TLR-4) signaling molecules. Vet Immunol Immunopathol. 2006 Aug 15;112(3-4):302-8. doi: 10.1016/j.vetimm.2006.03.003. Epub 2006 Apr 18.
Pubmed: 16621030
Rottenberg S, Schmuckli-Maurer J, Grimm S, Heussler VT, Dobbelaere DA: Characterization of the bovine IkappaB kinases (IKK)alpha and IKKbeta, the regulatory subunit NEMO and their substrate IkappaBalpha. Gene. 2002 Oct 16;299(1-2):293-300. doi: 10.1016/s0378-1119(02)01011-9.
Pubmed: 12459277
Harhay GP, Sonstegard TS, Keele JW, Heaton MP, Clawson ML, Snelling WM, Wiedmann RT, Van Tassell CP, Smith TP: Characterization of 954 bovine full-CDS cDNA sequences. BMC Genomics. 2005 Nov 23;6:166. doi: 10.1186/1471-2164-6-166.
Pubmed: 16305752
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Pubmed: 19390049
Lee EK, Kehrli ME Jr, Taylor MJ: Cloning and sequencing of cDNA encoding bovine tumor necrosis factor (TNF)-receptor I. Vet Immunol Immunopathol. 1998 Feb 27;61(2-4):379-85.
Pubmed: 9613449
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0063792
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