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Pathway Description
p53 Signaling Pathway
Rattus norvegicus
Category:
Metabolite Pathway
Sub-Category:
Signaling
Created: 2018-08-23
Last Updated: 2019-09-15
p53, named for its apparent molecular mass of 53 kilodaltons via SDS-PAGE analysis, is a protein that functions as a tumour suppressor and plays an important role in cell cycle regulation and cancer prevention. Over 50% of all cancers are theorized to involve p53-inactivating mutations. DNA damage, activated oncogenes, and oxidative stress can all produce stress signals to activate the p53 protein which is a transcriptional activator of >2500 p53-regulated genes. Activation of p53-regulated genes will lead to cellular senescence, cell cycle arrest, or apoptosis. Activated p53-regulated genes will also communicate with nearby cells for the purpose of DNA repair or feedback loop set-up that can either strengthen or weaken the stress responses of the p53 protein.
References
p53 Signaling Pathway References
Han J, Sabbatini P, Perez D, Rao L, Modha D, White E: The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein. Genes Dev. 1996 Feb 15;10(4):461-77. doi: 10.1101/gad.10.4.461.
Pubmed: 8600029
Madison DL, Pfeiffer SE: Cloning of the 3' end of rat bax-alpha and corresponding developmental down-regulation in differentiating primary, cultured oligodendrocytes. Neurosci Lett. 1996 Dec 20;220(3):183-6. doi: 10.1016/s0304-3940(96)13263-8.
Pubmed: 8994223
Tilly JL, Tilly KI, Kenton ML, Johnson AL: Expression of members of the bcl-2 gene family in the immature rat ovary: equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased bax and constitutive bcl-2 and bcl-xlong messenger ribonucleic acid levels. Endocrinology. 1995 Jan;136(1):232-41. doi: 10.1210/endo.136.1.7828536.
Pubmed: 7828536
Eliseev RA, Malecki J, Lester T, Zhang Y, Humphrey J, Gunter TE: Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect. J Biol Chem. 2009 Apr 10;284(15):9692-9. doi: 10.1074/jbc.M808750200. Epub 2009 Feb 19.
Pubmed: 19228691
Sato T, Irie S, Krajewski S, Reed JC: Cloning and sequencing of a cDNA encoding the rat Bcl-2 protein. Gene. 1994 Mar 25;140(2):291-2. doi: 10.1016/0378-1119(94)90561-4.
Pubmed: 8144041
Markiewicz DA, McKenna WG, Flick MB, Maity A, Muschel RJ: The effects of radiation on the expression of a newly cloned and characterized rat cyclin B mRNA. Int J Radiat Oncol Biol Phys. 1994 Jan 1;28(1):135-44. doi: 10.1016/0360-3016(94)90151-1.
Pubmed: 8270434
Trembley JH, Kren BT, Steer CJ: Posttranscriptional regulation of cyclin B messenger RNA expression in the regenerating rat liver. Cell Growth Differ. 1994 Jan;5(1):99-108.
Pubmed: 8123599
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. doi: 10.1101/gr.2596504.
Pubmed: 15489334
Riabowol K, Draetta G, Brizuela L, Vandre D, Beach D: The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells. Cell. 1989 May 5;57(3):393-401. doi: 10.1016/0092-8674(89)90914-8.
Pubmed: 2541912
Choi KS, Eom YW, Kang Y, Ha MJ, Rhee H, Yoon JW, Kim SJ: Cdc2 and Cdk2 kinase activated by transforming growth factor-beta1 trigger apoptosis through the phosphorylation of retinoblastoma protein in FaO hepatoma cells. J Biol Chem. 1999 Nov 5;274(45):31775-83. doi: 10.1074/jbc.274.45.31775.
Pubmed: 10542199
Yoshida T, Schneider EL, Mori N: Cloning of the rat Gadd45 cDNA and its mRNA expression in the brain. Gene. 1994 Dec 30;151(1-2):253-5. doi: 10.1016/0378-1119(94)90666-1.
Pubmed: 7828885
Yoshida T, Okazaki T, Hughes PE, Schneider EL, Mori N: Cloning of rat GADD45 gene and induction analysis following ionizing radiation in vivo. FEBS Lett. 1996 Feb 12;380(1-2):87-92. doi: 10.1016/0014-5793(96)00012-9.
Pubmed: 8603754
Matsumoto K, Moriuchi T, Koji T, Nakane PK: Molecular cloning of cDNA coding for rat proliferating cell nuclear antigen (PCNA)/cyclin. EMBO J. 1987 Mar;6(3):637-42.
Pubmed: 2884104
Zhou J, Ren K, Liu X, Xiong X, Hu X, Zhang J: A novel PDIP1-related protein, KCTD10, that interacts with proliferating cell nuclear antigen and DNA polymerase delta. Biochim Biophys Acta. 2005 Jul 10;1729(3):200-3. doi: 10.1016/j.bbaexp.2005.05.005.
Pubmed: 15982757
Tamura K, Kanaoka Y, Jinno S, Nagata A, Ogiso Y, Shimizu K, Hayakawa T, Nojima H, Okayama H: Cyclin G: a new mammalian cyclin with homology to fission yeast Cig1. Oncogene. 1993 Aug;8(8):2113-8.
Pubmed: 8336937
Bianchi S, Fabiani S, Muratori M, Arnold A, Sakaguchi K, Miki T, Brandi ML: Calcium modulates the cyclin D1 expression in a rat parathyroid cell line. Biochem Biophys Res Commun. 1994 Oct 28;204(2):691-700. doi: 10.1006/bbrc.1994.2515.
Pubmed: 7980531
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0063782
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