PathBank

Pathway Description

Dopamine Activation of Neurological Reward System

Rattus norvegicus

Category:

Metabolite Pathway

Sub-Category:

Signaling

Created: 2018-08-31

Last Updated: 2019-09-12

In the nervous system, dopamine acts as a neurotransmitter with roles in motor control, motivation, arousal, cognition, and reward. The mesolimbic pathway is the main pathway associated with reward, and the dopaminergic neurons of this pathway are found in the substantia nigra (SNc) and ventral tegmental area (VTA) of the midbrain. Dopamine acts on different G protein-coupled receptor subtyes. The D1-class (D1 and D5) receptors stimulate cAMP production by activating adenylyl cyclase, which activates the reward pathway. The D2-class (D2, D3, and D4) subtypes act oppositely, inhibiting cAMP production by inhibiting adenylyl cyclase. The differing distributions of the receptor subtypes mean that complex outputs often produce a synergistic effect, despite the receptor subtypes having opposite molecular effects (PMID: 20925949, 21303898).

References

Dopamine Activation of Neurological Reward System References

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This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from SMP0000308

	Adenosine triphosphate
	cAMP
	Dopamine
	Guanosine diphosphate
	Guanosine triphosphate
	Magnesium
	Pyrophosphate

	Adenylate cyclase type 2
	cAMP-dependent protein kinase catalytic subunit beta
	D(1A) dopamine receptor
	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

		Adenosine triphosphate
		cAMP
		Dopamine
		Guanosine diphosphate
		Guanosine triphosphate
		Magnesium
		Pyrophosphate

		Adenylate cyclase type 2
		cAMP-dependent protein kinase catalytic subunit beta
		D(1A) dopamine receptor
		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
		Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

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Dopamine Activation of Neurological Reward System

Dopamine Activation of Neurological Reward System References